background and objectives: cardiovascular disease is the most common cause of death in developed countries. in addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis,  (we investigated whether helicobacter pylori infection is related to prevalence of coronary heart dise...

BACKGROUND Atherosclerotic aortic arch plaques (AAP) have been linked to an increased risk of thrombo-embolic events as a cause of acute ischemic stroke of undetermined etiology. OBJECTIVES To find out the presence of atherosclerotic plaques in aortic arch and their potential role as a source of embolism in cerebral infarction of undetermined etiology. METHODS We performed trans-esophageal ...

objective(s): atherosclerosis is the main leading cause of cardiovascular diseases. the purpose of this study was to assess the potential preventive effect of egg yolk hdl on the atherosclerosis plaque formation. materials and methods: thirty rabbits were divided into five groups: a; normal diet, b; hyper-cholesterolemic diet, c; hypercholesterolemic + 400 mg/kg egg yolk hdl d; hypercholesterol...

Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein secreted by activated macrophages, generates reactive intermediates that oxidize lipoproteins in vitro. To explore the potential role of myeloperoxidase in the development of atherosclerosis, we determined whether th...

To our knowledge, the utility of coronary covered stents in the treatment of atherosclerotic carotid artery stenosis has not been defined in the English-language literature. Covered stents may prevent microembolic complications in select atherosclerotic carotid lesions, as they exclude the atherosclerotic lesion from the circulation by pressing the plaque against the vessel wall. Our early clin...

The few studies that have assessed the association between symptomatic atherosclerotic disease and risk of cancer have had conflicting results. In addition, these studies ascertained participants either from treatment settings (ie, service-based studies) or by using a records linkage system (ie, medical records of patients evaluated at clinics or hospitals) and, therefore, were prone to selecti...

OBJECTIVE The aim of this study was to assess whether contractile response of arteries to aqueous component of cigarette smoke extract (CSE) may be modulated in atherosclerotic arteries. METHODS Thoracic aortas were isolated from control rabbits and from 1.5% cholesterol-fed rabbits, all of which had visible advanced atheromatous surface changes on the aortas. CSE was prepared by bubbling mai...

Recombinant adenoviruses are the most efficient vectors with which to perform arterial gene transfer. Previous in vivo studies of adenovirus-mediated arterial transfection, however, have been performed using normal or endothelium-denuded arteries. It is unclear whether these results can be extended to atherosclerotic arteries. Accordingly, this study was designed to (a) assess the feasibility o...

BACKGROUND We have reported that human mononuclear leukocytes contain large amounts of angiotensin II (Ang II). The goal of the present study was to test the hypothesis that Ang II is present in monocyte/macrophages in atherosclerotic lesions. METHODS AND RESULTS Segments of thoracic aorta and left circumflex coronary artery were obtained from 3 groups of cynomolgus monkeys: normal, atheroscl...

OBJECTIVE Atherosclerotic cerebral aneurysms are known to increase occurrence of thromboembolic events and occlusion of perforator vessels intraoperatively due to pathological changes in the vessels themselves. In the current study, we analyzed the points to be considered during surgery for atherosclerotic cerebral aneurysms and the postoperative results. MATERIALS AND METHODS We retrospectiv...