Athymic nude mice carry neither conventional T cells nor NKT cells of thymic origin. However, NK1.1(-)TCR(int) cells are present in the liver and other immune organs of athymic mice, because these lymphocyte subsets are truly of extrathymic origin. In this study, we examined whether extrathymic T cells had the capability to protect mice from malarial infection. Although B6-nu/nu mice were more ...

Congenitally athymic (nude) mice accepted for their lifetime intact skin grafts from distantly related mammals (cat, human) and birds (chicken). They also failed to immunologically reject skin grafts from reptiles (lizards) and amphibians (tree frog), although the skin in these grafts underwent varying degrees of disorganization. A definitive role for the thymic defect in this failure to reject...

Three thyroid stimulators; LATS, TSH, and cholera toxin, have been tested by bioassay using congenitally athymic homozygous mice (nu/nu), nude mice and control littermates (nu/+) possessing normal thymic function. nu/+ Animals showed a response to LATS similarly to normal white mice of the ddN strain. The assay response to LATS in nu/nu animals was about half that in normal mice. TSH also showe...

The expression of T cell antigen receptors (TCR) in congenitally athymic (nude) mice has been investigated. Lymph node T cells from 4-5-mo-old athymic mice expressed full-length transcripts for the TCR alpha and beta chains at a level two-to three-fold lower than normal littermate (nu/+) controls. Low levels of expression of TCR protein at the surface of a proportion of nude T cells was demonst...

Murine intestinal intraepithelial lymphocytes (IEL) from unprimed thymus-bearing and athymic nude mice were characterized according to the expression of murine lymphocyte antigenic markers and cytotoxic activity. The majority of IEL from thymus-bearing mice were Lyt-2+, L3T4- lymphocytes, over half of which did not express Thy-1 surface antigens. Nude IEL and spleen cells were void of Thy-1+ ce...

BACKGROUND Synovial sarcoma represents one of the most frequent malignant tumours of soft tissues. Its prognosis is poor because of chemoresistance and high metastatic potential. Improvement of synovial sarcoma outcome requires well-characterized animal models in which to evaluate novel therapeutic options. The aim of this study was to establish a reproducible synovial sarcoma model in athymic ...