نتایج جستجو برای: atp binding cassette transporter

تعداد نتایج: 509133  

Journal: :Journal of bacteriology 2004
Gloria H Y Lau Ross T A MacGillivray Michael E P Murphy

The fbpABC operon in Neisseria gonorrhoeae encodes an ATP-binding cassette transporter required for iron uptake from the host ferric binding proteins. The gene for the nucleotide-binding domain (fbpC) expressed in Escherichia coli has intrinsic ATPase activity (0.5 mmol/min/mg) uncoupled from the iron transport process. The FbpC E164D mutant is found to have a 10-fold reduction in specific acti...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Cedric Orelle Tulin Ayvaz R Michael Everly Candice S Klug Amy L Davidson

The maltose transporter MalFGK(2) of Escherichia coli is a member of the ATP-binding cassette superfamily. A periplasmic maltose-binding protein (MBP) delivers maltose to MalFGK(2) and stimulates its ATPase activity. Site-directed spin labeling EPR spectroscopy was used to study the opening and closing of the nucleotide-binding interface of MalFGK(2) during the catalytic cycle. In the intact tr...

Ahmad Mohamad Zaki, Amel Sobhy El Sedfy, Heba Gaber El-Sheredy, Ola Hussein Elgaddar, Sara Ahmed Aglan,

Background: ATP-binding cassette membrane transporter G2 (ABCG2) gene is one of transporter family and well characterized for their association with chemoresistance. Promoter methylation is a mechanism for regulation of gene expression. O6-Methyl guanine DNA methyl transferase (MGMT) gene plays a fundamental role in DNA repair. MGMT has the ability to remove alkyl adducts from DNA at the O6 pos...

Journal: :PLoS Biology 2007
Peter P Borbat Kavitha Surendhran Marco Bortolus Ping Zou Jack H Freed Hassane S Mchaourab

We measured the amplitude of conformational motion in the ATP-binding cassette (ABC) transporter MsbA upon lipopolysaccharide (LPS) binding and following ATP turnover by pulse double electron-electron resonance and fluorescence homotransfer. The distance constraints from both methods reveal large-scale movement of opposite signs in the periplasmic and cytoplasmic part of the transporter upon AT...

Journal: :Biotechnology for Biofuels 2021

Abstract Background Lipid transporters play an essential role in lipid delivery and distribution, but their influence on seed oil production oilseed crops is not well studied. Results Here, we examined the effect of two transporters, FAX1 ( fatty acid export1 ) ABCA9 ATP-binding cassette transporter subfamily A9 metabolism plant Camelina sativa . Overexpression (OE) increased weight size, with ...

Elevated expression of the drug efflux transporter ABCG2 seems to correlate with multidrug resistance of cancer cells. Specific COX-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. To clarify whether ABCG2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of ABCG2 in breast cancer cell lines ...

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