BACKGROUND Health information technology can enhance self-management and quality of life for patients with chronic disease and overcome healthcare barriers for patients with limited English proficiency. After a randomized controlled trial of a multilingual automated telephone self-management support program (ATSM) improved patient-centered dimensions of diabetes care in safety net clinics, we c...

During the carcinogenesis process, tumour cells often have a more rapid proliferation potential than cells that participate in blood capillary formation by neoangiogenesis. As a consequence of the poorly organized vasculature of various solid tumours, a limited oxygen delivery is observed. This hypoxic mechanism frequently occurs in solid cancers and can lead to therapeutic resistance. The pres...

Algebraic Thinking Skills (ATS) are one of the skills that students need to master in order solve non-routine problems. These also necessary as a foundation for preparing enter university studies and fields work require logical analytical thinking. However, Malaysian students' performance solving algebraic problems still needs be satisfactory, according TIMSS 2019 PISA 2018 reports. Therefore, ...

  Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced ...

BACKGROUND AND PURPOSE: Cu-diacetyl-bis(N-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features amongMR imaging and Cu-diacetyl-bis(N-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[C]methionine)-PET in gliomas. MATERIALSANDMETHODS: Weenrolled 23 patientswhounderwent Cu-diacetyl-bis(N-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who...

PURPOSE Tumor redox is an important factor for cancer progression, resistance to treatments, and a poor prognosis. The aim of the present study was to define tumor redox (over-reduction) using 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) PET and compare its prognostic potential in head and neck cancer (HNC) with that of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG). METHODS Thirty HN...

Copper(II)bis(thiosemicarbazonato) complexes such as [(64)Cu]Cu-ATSM continue to be investigated for positron emission tomography (PET) imaging of tumour hypoxia. However, the currently proposed mechanisms for the mode of action of these complexes are unable to account fully for their observed biological behaviour. In order to examine the roles of the copper metal and the ligand, we designed a ...

The clarity of images degrades significantly due to the impact weather conditions such as fog and haze. Persistent particles scatter light, attenuating reflected light from scene, dispersed atmospheric will mix with received by camera affecting image contrast in both outdoor indoor images. Conventionally, scattering model (ATSM) is a often used recover hazy In ATSM, two unknown factors/paramete...

Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia, rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which primarily consist of aggregated α-synuclein protein, and is accompanied by the loss of monoaminergic neurons. Current therapeutic strategies only give symptomatic relief of motor impairment and do not address the...