Blood smears stained with Wright-Giemsa were obtained from 1 24 patients with pathologically confirmed cutaneous T cell lymphoma (CTCL). 70 patients with various other cutaneous disorders, and ten healthy adult volunteers. These were examined in a blinded fashion for atypical lymphocytes with cerebriform nuclei (CLs). which were characterized further according to cell diameter. CLs. compricing ...

The association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment o...

A case of a 62-year-old woman with recurrent subcutaneous nodules, fever and pancytopenia diagnosed as subcutaneous T-cell lymphoma is presented. Incision biopsy revealed lobular panniculitis with an inflammatory infiltrate of atypical T lymphocytes. She was treated with 7 courses of CHOP with transient remission, and she died after 17 months of disease from fatal hemorrhagic complications due ...

A young male developed hearing loss, vertigo, headache and facial palsy. Neurological examination did not show any abnormalities. Two years later, cervical lymphadenopathy, hepatosplenomegaly and atypical lymphocytes in peripheral blood revealed leukemia. At the same time, acquired ichthyosis was observed. Subsequently, neurological abnormalities revealed myelopathy associated with HTLV-1, due ...

Ichthyosiform mycosis fungoides (MF) is a rare variant of MF, occurring in 3.5% of MF patients according to one study (1, 2). Patients with ichthyosiform MF exhibit clinical manifestations similar to those of acquired ichthyosis; histologically, however, they show epidermotropism of atypical lymphocytes. Ichthyosiform MF is characterized by indolent course and usually good response to photother...

Recent studies have advanced our understanding of the pathophysiology autoimmune gastritis, particularly its molecular aspects. The most noteworthy recent advancement lies in identification several candidate genes implicated pathogenesis pernicious anemia through genome-wide association studies. These include PTPN22, PNPT1, HLA-DQB1, and IL2RA. also directed attention towards other such as ATP4...

BACKGROUND AND OBJECTIVE Although the finding of trisomy 12 in B-cell malignancies has been extensively documented especially in B-CLL, little is known about the clonal involvement of different tissues and there are few sequential studies documenting the development of trisomy 12 during the course of the disease. The aim of this study was, therefore, to: 1) ascertain the prevalence of trisomy 1...

Thyroid hormone (TH) regulation of cellular proliferation was demonstrated, but their effect and involved mechanisms on lymphocyte activity has not been elucidated. Also, differential expression of protein kinase C (PKC) isoenzymes and high nitric oxide synthase (NOS) activity were described on tumor respect to normal T lymphocytes. Here direct actions that TH exert on normal T lymphocytes and ...