A large number of auto-immune diseases are treated with rituximab, an antibody against CD20 that depletes most of the B-cells in the organism. The response to this treatment depends largely on the disease and the type of lymphoid cells involved in the auto-immune process. We recently reported that B-cell depletion in immune thrombocytopenia induced the appearance of pathogenic long-lived plasma...

Abstract The commensal microflora collection known as microbiota has an essential role in maintaining the host's physiological homeostasis. a vital induction and regulation of local systemic immune responses. On other hand, system involves compositions. Optimal microbiota-immune cross-talk is for protective responses to pathogens tolerance self harmless environmental antigens. Any change this s...

Introduction: Gluten is a protein found in grains.  Research has shown that the gluten that is in grains of wheat, barley, rye, and oats (to a lesser degree) is toxic to many individuals.  While gluten is essential for the make-up of these 4 grains, our bodies do not need it. Is it healthful?  The protein in today’s wheat is poorly digested and can be harmful.  An estimated 95% of prepared fo...

Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral axillary and inguinal lymphadenopathy as well as auto-immune hemolytic anemia. T...

AIM To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease. METHODS Levels of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy con...

Recorded observations suggest strongly but not conclusively that auto-immunity is a factor in the pathogenesis of at least some forms of juvenile diabetes mellitus. This view is based on the occasional association of juvenile diabetes with Hashimoto's disease, which is a well-known example of auto-immunity, the presence of thyroid antibodies in some cases of diabetes, and the pathohistological ...