Patients with solid tumors are increasingly being treated by autologous bone marrow transplantation (BMT). Although response rates appear to be increased, disease recurrence is the commonest cause of treatment failure. Whether relapse is entirely due t o residual disease in the patient or arises also from infiltrating malignant cells contained in the autologous marrow transplant has not been re...

Summary Hepatosplenic γ/δ T-cell lymphoma (HSTL) is a very rare, aggressive extranodal affecting mainly young adults. Clinically, presents with symptomatic hepatosplenomegaly and systemic symptoms but without lymphadenopathy. The diagnosis confirmed after careful evaluation of bone marrow liver biopsies or, in some cases, diagnostic splenectomy. Overall, survival short regardless chemotherapy r...

We used an in vitro measure of drug activity to predict the efficacy of ex vivo purging of leukemic cells from autologous bone marrow grafts. We previously found that the myeloid progenitor cell (CFU-GM) content of the marrow grafts after ex vivo purging with 4-hydroperoxycyclophosphamide (4-HC) correlates with time to hematologic recovery after autologous bone marrow transplantation in patient...

The purpose of this study is to compare the therapeutic effects between autologous and allogenic bone-marrow-derived mesenchymal stem cell (MSC) transplantation in experimentally-induced spinal cord injury (SCI) of dogs. Thirty adult Beagle dogs (control group=10, autologous group=10, and allogenic group=10) were used in this study. Prelabeled MSCs were intrathecally transplanted through the lu...

Elimination of neoplastic B cell populations from autologous bone marrow grafts also removes normal B lymphocytes. This is potentially hazardous for the reconstitution of the immune system in patients undergoing high-dose chemotherapy and total body irradiation followed by autologous marrow rescue. Five pediatric patients with B cell non-Hodgkin's lymphoma in first remission undergoing such a r...

Stem cell transplantation is the only curative treatment for a number of haematological and oncological diseases including lymphomas, leukaemias and several solid tumours. Recently the indications for this kind of treatment have been extended into other fields of internal medicine, e.g. autoimmune diseases. For stem cell transplantation it is necessary to have a graft consisting either of autol...

This study assessed the clinical efficacy of lamivudine and adefovir dipivoxil combined with autologous bone marrow stem cell transplantation as treatment for patients with hepatitis B and decompensated liver cirrhosis. In total, 77 patients with hepatitis B and decompensated liver cirrhosis were randomly divided into two groups. Under general symptomatic and supportive treatment, the patients ...

in the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. bone marrow mesenchymal stem cells (bm-mscs) possess all of these characteristics. one of the most important benefi...

1. Luppi M, Barozzi P, Rasini V, et al. Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet. Transplantation. 2002;74:131-132. 2. Luppi M, Barozzi P, Schulz TF, et al. Nonmalignant disease associated with human herpesvirus 8 reactivation in patients who have undergone autologous peripheral blood stem cell trans...