In extensively modified landscapes, how the matrix is managed determines many conservation outcomes. Recent publications revise popular conceptions of a homogeneous and static matrix, yet we still lack an adequate conceptual model of the matrix. Here, we identify three core effects that influence patch-dependent species, through impacts associated with movement and dispersal, resource availabil...

This work investigates the effect of the sequential availability of ZnO nanoparticles, (nanorods of ∼40nm) loaded within a degradable poly(lactic acid) (PLLA) matrix, in cell differentiation. The system constitutes a dynamic surface, in which nanoparticles are exposed as the polymer matrix degrades. ZnO nanoparticles were loaded into PLLA and the system was measured at different time points to ...

Parallelization of generalized matrix-matrix multiplication is crucial for achieving high performance required in many situations. Parallelization performed using contemporary compilers is not sufficient enough to replace expert-tuned multi-threaded implementations or to get close to their performance. All competitive solutions require previously optimized external implementations that cannot b...

Making an informed decision with regards to a suitable business location or site selection for organizations is becoming challenging for business decision makers globally; and even more challenging in business environment that are saddled with uncertainties. The continues raise of multiple criteria variation of site preferences has also necessitated the application of advanced decision making t...

The Adapted PageRank Algorithm (APA) proposed by Agryzkov et al. provides us a method to establish a ranking of nodes in an urban network. We can say that it constitutes a centrality measure in urban networks, with the main characteristic that is able to consider the importance of data obtained from the urban networks in the process of computing the centrality of every node. Starting from the b...

Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the extracellular matrix (ECM). Mechanical activation of TGF-β1 is currently understood as an acute process that depends on the contractile force of cells. However, we show that ECM remodeling, preceding the activation step, mechanically pri...

As a classic natural language processing technology, topic detection recently attracts more research interests due largely to the rapid development of microblog. The most challenging issue in microblog topic detection is sparse data problem. In this paper, the temporal-author-topic (TAT) model is designed to accomplish microblog topic detection in two phases. In the first phase, the TAT model i...

Inadequate target exposure is a major cause of high attrition in drug discovery. Here, we show that a label-free method for quantifying the intracellular bioavailability (Fic) of drug molecules predicts drug access to intracellular targets and hence, pharmacological effect. We determined Fic in multiple cellular assays and cell types representing different targets from a number of therapeutic a...

The ability to learn at different resolutions in time may help overcome one of the main challenges in deep reinforcement learning — sample efficiency. Hierarchical agents that operate at different levels of temporal abstraction can learn tasks more quickly because they can divide the work of learning behaviors among multiple policies and can also explore the environment at a higher level. In th...

Visual working memory exhibits age effects that are amongst the largest observed in the cognitive aging literature. In this research we investigated whether or not older adults can benefit from visual symmetry and semantic availability, as young adults typically do. Visual matrix pattern tasks varied in terms of the perceptual factor of symmetry (Experiment 1), as well as the availability of vi...