Post kala-azar dermal leishmaniasis (PKDL) is a non-ulcerative lesion of the skin caused by Leishmania donovani, which is usually seen after completion of treatment of the kala-azar. The condition is yet to be reported from Nepal. We document and report for the first time a case of PKDL in Nepal.

The pathogenesis of post-kala-azar dermal leishmaniasis (PKDL) is complex. Only 5 to 10% of kala-azar patients develop this dermal complication, and it is not known whether this is due to changes in the parasite genome or some host factors. Here, we report the whole-genome sequence and annotated genes of the whole genome of the PKDL strain.

We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.

INTRODUCTION Human immunodeficiency virus (HIV) coinfection with Leishmania infantum or Leishmania donovani, the agents of visceral leishmaniasis (or kala-azar), has become a fatal public health problem in the tropics where kala-azar is endemic. METHODS The clinical presentation of patients with HIV and L. infantum coinfection is described using two unique databases that together produce the ...

BACKGROUND Studies performed over the past decade have identified fairly consistent epidemiological patterns of risk factors for visceral leishmaniasis (VL) in the Indian subcontinent. METHODS AND PRINCIPAL FINDINGS To inform the current regional VL elimination effort and identify key gaps in knowledge, we performed a systematic review of the literature, with a special emphasis on data regard...

thirty eight patients with visceral leishmaniasis were reviewed, age ranged from 2 months to 10 years, 74% above 3.5 y, with 24% affection in infants (7 to 12 m), with slight male predilection. all the patients had weight loss, splenomegaly and hepatomegaly, 97% with fever, 92% had positive serology and 63% had positive bone marrow findings. a few patients presented with atypical clinical findi...

in a descriptive analytical study in six villages in meshkin shahr area, the important endemic focus of kala-azar in northwest iran, a kap study was carried out on various aspects of kala-azar in a total of 245 young mothers selected randomly and interviewed the results of the present investigation showed that 93.5% of the mothers were illiterate and only 2.4% of them had acceptable knowledge a...