Introduction: Recurrent Pregnancy Loss (RPL) is a heterogeneous disease which consisting of three or more successive abortions before 20 weeks of pregnancy. The cytokines that secreted by Th1 cells (IL-1, TNFα and IFNγ) were described as etiologic factors in RPL. The aim of this study was investigate to association between recurrent pregnancy loss and IL-1 receptor antagonist gene (IL-1RN) intr...

BACKGROUND It has been demonstrated that insulin signaling pathway related genes have important roles in polycystic ovary syndrome (PCOS) risk. The goal of present investigation was to assess the potential association between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs and PCOS. METHODS 50 women with PCOS and 47 normal controls entered the study. NsiI and PmlI SNPs in the INSR gene w...

BACKGROUND Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract that includes two entities, Crohn's disease (CD) and ulcerative colitis (UC). As with other complex diseases, both genetic susceptibility and environmental factors play role in the pathogenesis of these diseases. The tumor necrosis factor α (TNF-α) gene is located in the IBD3...

Abstract Background Obesity is a health problem defined by surplus body fat accumulation and one of the leading causes morbidity mortality. Earlier studies indicated influence brain-derived neurotrophic factor ( BDNF ) molecular alterations in development obesity. One these variations G196A single nucleotide polymorphism (Val66Met; SNP rs6265), which impairs intracellular trafficking reduces se...

Some genes have an unproven role in the pathogenesis of Rheumatoid arthritis (RA). One of these suspected genes is the Mediterranean fever (MEFV) gene. MEFV is responsible for familial Mediterranean fever (FMF). Currently, more than 100 FMF-associated mutations of the MEFV gene have been identified. With most located on exon 10, five of these: E148Q, M680I, M694V, M694I, and V726A account for m...

objective: depression and anxiety literature in iran is short of cultural/indigenous studies, especially with regard to azeri ethnic group. this study was carried out in order to identify depression and anxiety aspects in azeri ethnic group. methods: in a cross sectional qualitative design, 32 azeri informants (14 patients, 13 lay people, and 5 professionals) recruited in the study using purpos...