Production of amyloid-b protein (Ab) is initiated by a b-secretase that cleaves the Ab precursor protein (APP) at the N terminus of Ab (the b site). A recently identified aspartyl protease, BACE, cleaves the b site and at residue 11 within the Ab region of APP. Here we show that BACE2, a BACE homolog, cleaves at the b site and more efficiently at a different site within Ab. The Flemish missense...

BACKGROUND In order to identify novel chemical classes of β-secretase (BACE-1) inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA), was proposed to summarize most of the information from the original scoring functions and re-rank the results from the virtual screening against BACE-1. METHOD Given a training set (50 BACE-1 inhibitors and 9950 inactive diverse compou...

B ecky Bace, one of the luminaries of computer security, grew up in Birmingham, Alabama. She spent 12 years at the US National Security Agency (NSA), where her work focused on intrusion detection and cryptography. Currently, Bace is a venture consultant with the venture capital firm Trident Capital in Palo Alto, California. Featured here is an excerpt adapted from the full interview between Bac...

Substitution with Y affects phase formation and the local cation stoichiometry of Ce-rich Fe-rich phases BaCe 1−( x + z ) Fe O 3− δ self-generated composites. This is particular importance for water uptake in these compounds.

Alzheimer's (AD) is the leading cause of dementia among elderly people. Considering the complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted drugs for its suppression. β-amyloid cleavage enzyme (BACE-1) and acetylcholinesterase (AChE), being important for AD progression, have been considered as promising drug targets. In this study, a robust and highly predicti...

In Alzheimer's disease (AD), progressive accumulation of β-amyloid (Aβ) peptides impairs nicotinic acetylcholine receptor (nAChR) function by a mechanism that may involve α7 and α4β2-nAChR subtypes. Additionally, the beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE), the rate-limiting enzyme in the pathogenic Aβ production pathway, is expressed at high levels in hippocampal and c...

BACKGROUND β-Amyloid protein (Aβ) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Aβ levels can attenuate the isoflurane-induced caspase-3 activation. We therefore set out to determine the effects of RNA interference-mediated silencing of amyloid precursor protein (APP) and β-site AP...

A growing body of evidence has demonstrated amyloid plaques in aged brain; however, little attention has been given to amyloid precursor protein (APP) processing machinery during the healthy aging process. The amyloidogenic and non-amyloidogenic pathways, represented respectively by β- and α-secretases (BACE and TACE), are responsible for APP cleavage. Our working hypothesis is that the normal ...

Alzheimer’s Disease is a prominent neurodegenerative disorder affecting the age group 60 and above. Cholinergic hypothesis, amyloid β cascade, oxidative stress some of known etiologies marked importance to name few. We have undertaken computational analysis where fifteen phytochemicals were selected. These natural molecules studied analysed against acetylcholinesterase, butyrlcholinesterase, BA...