DNA topoisomerases (topos) are essential enzymes that participate in many cellular processes involving DNA. The presence of the DNA-gyrase genes in various mycoplasmas has been reported elsewhere. However, the characterization of DNA topo activity in mycoplasmas has not been previously undertaken. In this study, we characterized the topo activity in extracts of Mycoplasma fermentans K7 and inco...

The production of antifungal substances by bacteria has long been recognized and this knowledge is entering practical life through the use of bacterial antagonists to protect crops against their fungal enemies. Recently, it has become clear that in addition to diffusible substances, bacteria emit a wide range of volatile compounds into the atmosphere. Over the last ten years, evidence has accum...

Metabolic alteration of certain antagonists of pteroylglutamic acid’ t’o biologically utilizable compounds has been postulated as an explanation of the apparent ability of these analogues t’o promote the growth of a strain of l’etrahymena (1) and an antagonist-resistant strain of Streptococcus faecalis (2). Direct investigation of the possibility that bacterial and leucemic cells, which have be...

conclusions the bacterial isolates exhibited strong biofilm formation potential, while the extracts of acacia arabica significantly inhibited biofilm formation among the isolates and, therefore, could be executed in the development of cost-effective biofilm inhibitor medicines. results pseudomonas aeruginosa (kc417303-05), staphylococcus hemolyticus (kc417306), and staphylococcus hominis (kc417...

Background Mevalonate Kinase Deficiency (MKD) is one of the autoinflammatory fever syndromes, caused by mutations in the MKD gene. Systemic inflammatory symptoms may be mild to severe leading to early death, and recurrent bacterial infections frequently develop in the disease course. On demand NSAID and steroids are the most commonly used. Few case-reports suggested that interleukin-1 (IL-1) an...

First drugs which were largely used for chemotherapeutically and preventive use were the sulfonamides. Sulfonamides have a wide range of pharmacological activities such as against rheumatoid arthritis, anti-hypertensive, anti-epileptic, anti-bacterial, anti-protozoal, anti-fungal, non-peptidic vasopressin receptor antagonists, antiinflammatory, and translation initiation inhibitors. These sulfo...

The principle phytoestrogens isoflavones (coumestrol, genisteen, daidyein and equol) and lignin (enterolactone and enteroradiol) are low molecular weight diphenolic antimicrobial compound (phytoalexine) synthesized de novo in plants in respone to exposure to bacterial pathogens and may exert their biological activity by (i) mimicking the action of endogenous oestrogen (ii) acting as oestrogen a...