Calculations are presented of the rate of energy conversion of the barotropic tide into internal gravity waves above topography on the ocean floor. The ocean is treated as infinitely deep, and the topography consists of periodic obstructions; a Green function method is used to construct the scattered wavefield. The calculations extend the previous results of Balmforth et al. for subcritical top...

Betacellulin (BTC), a member of the epidermal growth factor (EGF) family of peptide growth factors, was purified from a growth-factor-enriched whey fraction of bovine milk by a combination of ion-exchange chromatography, gel-filtration chromatography, affinity chromatography and reverse-phase HPLC. Bovine BTC (bBTC) had an apparent molecular mass of 21-22 kDa on SDS/PAGE and exists in a glycosy...

The asymmetric unit of the title compound, [Zn3(HCO2)3(C9H3O6)(C3H7NO)3] n , contains one Zn ion, one formate ligand, one N,N-di-methyl-formamide (DMF) ligand and one-third of a benzene-1,3,5-tri-carboxyl-ate (btc) ligand situated on a crystallographic 3 axis. Each Zn(II) atom is coordinated by one O atom from a DMF ligand, two O atoms from two btc ligands and three O atoms from three formate l...

Biliary tract carcinoma (BTC) has a poor prognosis due to limited treatment options. There is, therefore, an urgent need to identify new targets and to design innovative therapeutic approaches. Among potential candidatemolecules, we evaluated the nonreceptor tyrosine kinase Src, observing promising antitumor effects of its small-molecule inhibitor saracatinib in BTC preclinical models. The pres...

Image compression is used to reduce the size of digital image files in order to lessen the physical storage and transmission bandwidth costs. The main challenge in image compression is reducing the file size while maintaining much of the visual information. In this study, we explore one class of image compression techniques – the Block Truncation Coding (BTC) – and propose a new variant which w...

We recently reported several driver genes of biliary tract carcinoma (BTC) that are known to play important roles in oncogenesis and disease progression. Although the need for developing novel therapeutic strategies is increasing, there are very few BTC cell lines and xenograft models currently available for conducting preclinical studies. Using a total of 88 surgical BTC specimens and 536 immu...

OBJECTIVE To examine the issues surrounding the development and implementation of a behind-the-counter (BTC) category of medications. DATA SOURCES Testimony from organizations submitting comments to the Food and Drug Administration (FDA) panel hearings in November 2007, the 2009 final report of the U. S. General Accounting Office regarding a BTC drug category, literature review of research th...

In the title adduct, 3C(13)H(9)N·C(9)H(6)O(6) or (acr)(3)(btc), associ-ations of one btc and three acr molecules linked by O-H⋯N hydrogen bonds occur. C-H⋯O interactions also occur, resulting in a cyclic hydrogen-bonded synthon R(2) (1)(6). The acr mol-ecules and the btc mol-ecules also form slipped or offset π-π stacking inter-actions [centroid-centroid distances of 3.5212 (17) Å for btc rings...

PIK3CA mutation is considered a good candidate for targeted therapies in cancers, especially biliary tract cancer (BTC). We evaluated the utility of cell free DNA (cfDNA) from serum by using droplet digital PCR (ddPCR) as an alternative source for PIK3CA mutation analysis. To identify matching archival tumour specimens from serum samples of advanced BTC patients, mutation detection using ddPCR ...