Our intention in this paper is to develop an explanatory account of the special characteristics of periphrastic expressions by refining the traditional notion of PARADIGM employed within inferential-realizational approaches to morphology (Anderson 1992, Aronoff 1994, Zwicky 1990, Stump 1993, 2001). Our proposal draws on this notion in order to develop a substantive reconceptualization of the fo...

BACKGROUND A major consequence of malnutrition in cystic fibrosis (CF) patients is the loss of lean body mass (LBM) and the subsequent impairment of respiratory muscle function. AIM To determine whether insulin-like growth factor I (IGF-I) could be related to the LBM depletion and the evolution of respiratory disease in CF patients. METHODS LBM was evaluated by dual energy x ray absorptiome...

OBJECTIVE Analysis of energy expenditure (EE) in mice is essential to obesity research. Since EE varies with body mass, comparisons between lean and obese mice are confounded unless EE is normalized to account for body mass differences. We 1) assessed the validity of ratio-based EE normalization involving division of EE by either total body mass (TBM) or lean body mass (LBM), 2) compared the in...

BACKGROUND Decreased lean body mass (LBM) is common in breast cancer survivors yet currently there is a lack of information regarding the determinants of LBM after treatment, in particular, the effect of physical activity and dietary factors, such as long-chain omega-3 fatty acids (LCn-3) on LBM and LBM function. This cross-sectional study explored associations of LBM and function with LCn-3 in...

Extracellular vesicles, specifically microparticles (MPs), are rapidly gaining attention for their capacity to act as biomarkers for diagnosis, prognosis, or responsiveness to therapy in lung disease, in keeping with the concept of precision medicine. However, MP analysis by high-sensitivity flow cytometry (FCM) is complicated by a lack of accurate means for MP enumeration. To address this gap,...

We propose a numerical approach based on the Lattice-Boltzmann (LBM) and Immersed Boundary (IB) methods to tackle the problem of the interaction of solids with an incompressible fluid flow, and its implementation on heterogeneous platforms based on data-parallel accelerators such as NVIDIA GPUs and the Intel Xeon Phi. We explain in detail the parallelization of these methods and describe a numb...

BACKGROUND Indirect methods such as anthropometry (A), Watson formula (W), creatinine kinetics (CK), and body electrical impedance (BEI) are increasingly applied to determine total body water (TBW) and lean body mass (LBM) in dialysis patients. These methods share the disadvantage that they have been validated for healthy men only. We studied which of these four commonly applied methods can bes...

We report on recent progress and validation of a 3D hybrid model for naval hydrodynamics problems based on a perturbation method, in which both velocity and pressure are expressed as the sum of an inviscid flow with a viscous perturbation. The farto near-field inviscid flows can be solved with a Boundary Element Method (BEM), based on fully nonlinear potential flow theory, and the near-field pe...

STUDY OBJECTIVE To investigate the distribution of reduction in lean body mass (LBM) and whether LBM in legs (LBMlegs) can be a determinant of maximal exercise performance in COPD patients. METHODS Thirty-eight male outpatients with COPD (mean +/- SD FEV1, 47.4 +/- 24.0% of predicted) who underwent complete pulmonary function testing were classified into two groups according to FEV1 expressed...

BACKGROUND Reduced lean body mass (LBM) is one of the main indicators in malnutrition inflammation syndrome among patients on dialysis. However, the influence of LBM on peritoneal dialysis (PD) patients' outcomes and the factors related to increasing LBM are seldom reported. METHODS We enrolled 103 incident PD patients between 2002 and 2003, and followed them until December 2011. Clinical cha...