The development of new highly sensitive and selective methods for microarray-based analysis is a great challenge because, for many bioassays, the amount of genetic material available for analysis is extremely limited. Currently, imaging and detection of DNA microarrays are based primarily on the use of organic dyes. To overcome the problems of photobleaching and low signal intensities of organi...

objective(s): chitosan nanoparticles (cnps) were prepared based on the ionic gelation of chitoan with anionic compounds of ocimum basilicum leaf extract. materials and methods: after addition of ocimum basilicum leaf extract to chitosan solution, the physicochemical properties of the nanoparticles were determined by field emission scanning electron microscope (fesem), fourier transform infrared...

this article presents an experimental investigation on effects of morphology of nanoparticles on the viscosity nanofluids (nfs). water and ethylene glycol were used as base fluids. a two step method was used for preparation of nfs. sio2 nanoparticles, cnt and graphene nano sheets were dispersed in the base fluids separately with the volume fraction ranging from 0.05% to 1.5%. stability of the n...

The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model. Both metallic copper and copper oxide nanoparticles have been tested, with copper ion and zirconium oxide nanoparticles used as controls. Proteomic analysis highlighted changes in proteins implicated in ox...

This review covers the emerging field of nanobiotechnology, in which nanoparticles are applied to the analysis of biomolecules. Nanoparticles can be used in a variety of bioanalytical formats, and this review discusses four classes of use. First, nanoparticles as quantitation tags, such as the optical detection of quantum dots and the electrochemical detection of metallic nanoparticles. Second,...

Towards the goal of development of a generic nanomaterial delivery system and delivery of the 'as prepared' nanoparticles without 'further surface modification' in a generic way, we have fabricated a hybrid polymer capsule as a delivery vehicle in which nanoparticles are loaded within their cavity. To this end, a generic approach to prepare nanomaterials-loaded polyelectrolyte multilayered (PEM...

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Praveen Nedumpully Govindan Name of the doctoral dissertation Computational Modeling Investigating the Interactions of Proteins with Fullerene-based Nanoparticles Publisher School of Science Unit Department of Applied Physics Series Aalto University publication series DOCTORAL DISSERTATIONS 12/2013 Field of research Engineerin...

Abstract Background Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment. ...