Abstract: Neurotoxic organotin reagents currently play a key role in radical chemistry. As a result, this is an important area for development of new clean replacement reactions. The pharmaceutical industry in particular has had to avoid use of radical methodology for the formation of carbon–carbon bonds for this reason. With the current dawn in green chemistry, a host of new clean radical meth...

In this work, we describe the one-pot synthesis of α-amino nitrile units by concomitant addition alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in scope conditions are mild, inexpensive, easy to set-up, providing numerous nitriles good yields (34 examples, 41–94 % yield).

silica chloride converted benzyl or tert-butyl esters to the corresponding acid chlorides and alkyl chlorides. it also converted benzyl or tert-butyl phenyl ethers to the corresponding allcyl chlorides and phenol

nano-silica supported titanium tetrachloride (ticl4.sio2) was prepared and used as an acid catalyst for the 14-aryl or alkyl-14h-dibenzo[a,,j]xanthenesreaction under solvent-free conditions. compared to the classical 14-aryl or alkyl-14h-dibenzo[a,j]xanthenesreaction conditions, this method consistently has the advantage of excellent yields, mild reaction conditions, ease of workup, survival of...

P, adioactive S-alkyl glycerol ethers have been synlhesized with 3SS, 14C and 3tt labels as well as 311/35S double labels. Tile synthesized compounds were converted to various derivatives which can serve to characterize tile S-alkyl glycerol ethers. These included tile isopropylidene derivative, oxidation with periodate to the aldehyde followed by reduction with LiAIH4 to tile alcohol, and reac...

Non-activated alkyl halides are challenging substrates for cross-coupling reactions because they are reluctant to undergo oxidative addition and because metal alkyl intermediates are prone to beta-H elimination. Despite recent progress, well-defined catalysts are rare. We recently prepared Ni complexes with a chelating pincer-type bis(amino)amide ligand. The chloride complex [((Me)NN2)NiCl] is ...

Palladium-catalyzed cross-coupling reactions of alpha-aryl-beta,beta-difluoroenol silyl and alpha-aryl-beta-fluoroenol silyl ethers with aryl bromides proceed smoothly with good functional compatibility.

Iodine was demonstrated to be an efficient catalyst for disproportionation of aryl-substituted ethers under solvent-free reaction conditions. Variously substituted 1,1,1',1'-tetraaryldimethyl ethers were transformed into the corresponding diarylketone and diarylmethane derivatives. I2-catalyzed transformation of 4-methoxyphenyl substituted ethers yielded mono- and dialkylated Friedel-Crafts pro...

OBJECTIVES Administration of ethylene glycol monoalkyl ethers to rodents causes acute hemolytic anemia. Metabolic activation of these chemicals to alkoxyacetic acids is required to develop hemolytic effect. Current study was undertaken to compare the hemolytic activity of isopropoxyethanol (IPE) and phenoxyethanol (PhE) in male rats. The main goal of this study was to evaluate the role of alkyl...

Alkyl glyceryl ethers function mostly as skin-conditioning agents in cosmetic products applied to the skin and hair. The Cosmetic Ingredient Review expert panel reviewed the available animal toxicity and clinical data, including the low dermal absorption, and concluded that the alkyl glyceryl ethers are safe in the present practices of use and concentration described in this safety assessment.