Abstrad Cross-linking of B-cell membrane immunoglobulin (Ig) receptors induces growth arrest at G1-S, leading to apoptosis and cell death in the immature lymphomas WEHI-231 and CH31, but not in the CH12 B-cell line. In this system, which has been used as a model for Bcell tolerance, we have established that these lymphomas produce adive transforming growth fador (TGF8) when treated with anti-Ig...

Purpose: Approximately 50% of patients with diffuse large Bcell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a critical need to identify effective and targeted therapeutics for DLBCL. Experimental Design: Recent studies have highlighted the incidence of increased c-MYC pro...

The transcription factor PU.1 is essential for myeloid and Bcell development. Down-regulation of PU.1 by disruption of its 14-kb 5¶ upstream regulatory element induced acute myeloid leukemia, T-cell lymphoma, and chronic lymphocytic leukemia–like disease in murine models. In the present study, we found that PU.1 was down-regulated in the majority of human myeloma cell lines and a subset of fres...

Bone marrow monoclonal small B-cell infiltration (MSBC) associated with monoclonal B lymphocytosis (MBL), is present at a higher frequency in patients with diffuse large B-cell lymphoma (DLBCL). We have prospectively collected blood and bone marrow (BM) samples in patients with primary DLBCL at diagnosis to study the clonal relationship of MBL/MSBC with the paired DLBCL. MBL/MSBC were detected ...

neurolymphomatosis is a rare manifestation of non-hodgkin lymphoma characterized by infiltration of peripheral nerves, nerve roots, plexus and cranial nerves by malignant lymphocytes. this report presents positron emission tomography/computed tomography (pet/ct)imaging with 2-deoxy-2-18f-fluoro-d-glucose (18f-fdg) in 3 cases of non-hodgkin lymphoma with nerve infiltration, including one newly d...

Neurolymphomatosis is a rare manifestation of non-Hodgkin lymphoma characterized by infiltration of peripheral nerves, nerve roots, plexus and cranial nerves by malignant lymphocytes. This report presents positron emission tomography/computed tomography (PET/CT)imaging with 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG) in 3 cases of non-Hodgkin lymphoma with nerve infiltration, including one newly d...

background: lymphomas are a group of malignancies affecting b, t and nk cells. cox-2 enzyme is one of the known inflammatory factors which increase in the inflammation process. increase in cox-2 expression inhibits apoptosis and increases tumor cells invasion and angiogenesis. increase in the cox-2 gene expression is seen in a group of cancers .specific cox-2 inhibition also can be beneficial i...

Peripheral T/NK-cell lymphomas (PTCL) comprise a rare and heterogeneous group of malignancies accounting for approximately 10-15% of all nonHodgkin’s lymphomas (NHL) in Western countries. PTCL in general are characterized by an aggressive course and most studies revealed the T-cell phenotype as a negative prognostic marker. The international prognostic index (IPI) and T-cell specific prognostic...

Introduction The pathogenesis of rheumatoid arthritis (RA) involves systemic dysregulation of T and B lymphocytes resulting in immune responses against self-antigens, and ultimately leading to downstream effects such as cartilage destruction, pannus formation, and bone erosion. Clinical evidence for the role of B cells in RA includes the effectiveness of rituximab, an antibody designed to deple...

Identification of IL-6 and its pleiotropic functions IL-6 was originally identified as an antigen-nonspecific Bcell differentiation factor in the culture supernatants of mitogenor antigen-stimulated peripheral blood mononuclear cells that induced B cells to produce immunoglobulins [1,2], and was named B-cell stimulatory factor 2 (BSF-2). The cDNA encoding human BSF-2 was cloned in 1986 [3]. Sim...