A polymeric prodrug of prostaglandin E(1) (PGE(1)) was synthesized using galactosylated poly(L-glutamic acid hydrazide) (Gal-HZ-PLGA) as a biodegradable and targetable carrier to hepatocytes. Poly(L-glutamic acid hydrazide) was prepared by reacting poly(gamma-benzyl-L-glutamate) with hydrazine monohydrate, followed by reaction with 2-imino-2-methoxyethyl-1-thiogalactosides to obtain Gal-HZ-PLGA...

The title compound, C(14)H(13)N(3)O(2), was prepared by the reaction of 2-methoxy-benzyaldehyde with nicotinic acid hydrazide in methanol. The dihedral angle between the benzene and pyridine rings is 5.9 (3)°. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯O hydrogen bonds, leading to the formation of chains along the c axis; adjacent chains are linked via C-H⋯O and C-H⋯...

The title compound, C(18)H(15)N(3)O(2), was prepared by the reaction of 2-methoxy-naphthaldehyde with nicotinic acid hydrazide in methanol. The dihedral angle between the naphthalene ring system and the pyridine ring is 9.2 (3)°. An intra-molecular C-H⋯N hydrogen bond is observed. In the crystal structure, mol-ecules are linked into chains running along the c axis by inter-molecular N-H⋯O hydro...

By J. BURNS AND P. B. NEAME T lIE PERIODIC ACID-SCHIFF (PAS ) REACTION is generally accepted as the method of choice for demonstrating glycogen in blood cells. This reaction depends upon the presence, in glycogen, of vicinal glycols which are oxidized by periodic acid to dialdehydes. The latter are subsequently condensed with Schiff’s reagent to produce a magenta-red product, visible by light m...

Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l...

A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...

Development of immunomodulatory agents that enhance innate immune responses represents a promising strategy for combating infectious diseases. In the present studies, we screened a series of 71 arylcarboxylic acid hydrazide derivatives for their ability to induce macrophage tumor necrosis factor alpha (TNF-alpha) production and identified six such compounds, including one compound previously sh...

2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthofo...

ham University (Newcastle Division, King's College) 1957. 25. KORNBERG, H. and KREBS, H. A. Synthesis of cell constituents from C-units by a modified tricarboxylic acid cycle. Nature 179: 988-991. 1957. 26. BRADBEER, J. W. Some carbohydrate and acid conversions in Kalanchoe crenata. Ph.D. Thesis, Durham University (Newcastle Di-ision, King's College) 1954. 27. STILLER, M. Experiments on the rel...