نتایج جستجو برای: benzo
تعداد نتایج: 7873 فیلتر نتایج به سال:
CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Paradoxically, however, Cyp1a1-/- knockout mice are more sensitive to oral benzo[a]pyrene exposure, compared with wild-type Cyp1a1+/+ mice (Mol Pharmacol 65:1225, 2004). To further investigate the me...
The current study was conducted to evaluate the effects of three generation sources smoke (poplar, haloxylon, and white paper), smoking duration (2 4 h) meat contents (55 80%) on Polycyclic Aromatic Hydrocarbons (PAHs) levels sausages. results showed that there are a positive correlation between lignin content PAHs level smokes smoked total in both sausages increased significantly as from 2 h. ...
Data are presented which suggest that cigarette smoking, and to a lesser degree, urban pollution as indexed by benzo[a]pyrene are etiologic factors in the causation of lung cancer. The dose--response relationship to benzo[a]pyrene to lung cancer death rate in the urban community was estimated by using data on lung cancer deaths among coke oven workers. It appears to be an excess of 2--5 mumg/m3...
a fast and simple modified quechers (quick, easy, cheap, rugged and safe) extraction method based on spiked calibration curves and direct sample introduction was developed for determination of benzo[a]pyrene (bap) in bread by gas chromatography-mass spectrometry single quadrupole selected ion monitoring (gc/ms-sq-sim). sample preparation includes extraction of bap into acetone followed by clean...
The convenient and multigram synthesis of a linear benzo[b]dithiophene (BDT) structure is proposed (dimethyl 3,7-diamino-4,8-bis((2-methoxy-2-oxoethyl)thio)benzo[1,2-b:4,5-b’]dithiophene-2,6-dicarboxylate). starting materials are commercially available 2,3,5,6-tetrachloroterephthalonitrile methyl 2-mercaptoacetate, which undergo aromatic substitution, followed by cyclization reaction in basic c...
Study of interaction between catechol and tetraethylene glycol dichloride in the n-butanol media, resulting with benzo-15-crown-5 production. Production of nitroand amino-derivatives of benzo-15-crown-5. Determination of their thermogravimetric characteristics. keywords: benzo-15-crown-5, catechol, tetraethylene glycol dichloride, crown ether, gas liquid chromatography, chromate-mass spectrometry
The metabolism of [Wlbenzo(a)pyrene with isolated hepatocytes from 3-methylcholanthrene-treated rats was examined with the aid of high pressure liquid chromatography. Covalent binding of [SHlbenzo(a)pyrene metabolites to the intracellular DNA was investigated. The effects of (Ynaphthoflavone, salicylamide, trichloropropene oxide, and diethylmaleate, individually or combined, on the metabolism a...
The synthesis and docking studies of novel benzo[b][1,8]naphthyridines is discribed. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of b...
Selective synthesis of benzo[f]tetraphenes or benzo[g]chrysenes was achieved via aromatic C-F bond cleavage and unprecedented regioselective C-C bond formation depending upon the choice of aluminium reagents. On treatment with AlCl3, 2-(biphenyl-2-yl)-1-fluoronaphthalenes afforded exclusively benzo[f]tetraphenes via C-C bond formation on the carbon atom γ to the original position of the fluorin...
The metabolism of benzo(a)pyrene in cultured human colon has been investigated. Nontumorous colonie tissue was collected at the time of either surgery or "immediate autopsy" from patients with or without colonie cancer. After 24 hr in culture the expiants were exposed to [3H]benzo(a)pyrene for another 24 hr and the binding to cellular DMA and protein was measured. Two adducts, formed between be...
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