نتایج جستجو برای: benzodiazepine
تعداد نتایج: 4873 فیلتر نتایج به سال:
New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological evaluatio...
the cycloaddition reaction of diphenylnitrilimine on the 1,5-benzodiazepines has been studied. new molecules of triazolobenzodiazepines type have been isolated and characterized.
a quasi. experimental study was conducted to investigate the antagonistic effect of flumazenil on the recovery of patients above the age 50 year from anaesthesia receiving benzodiazepine products in one of iran medical sciences university hospital's operating rooms . a total of sixty middle aged patients were selected sequentially . thirty of them (12 females and 18 males ) were in...
BACKGROUND Whether long-term benzodiazepine users who participate in a family practice-based benzodiazepine discontinuation programme substitute benzodiazepines by other psychotropics is not clear. OBJECTIVE To evaluate the impact of a benzodiazepine discontinuation programme on non-benzodiazepine psychotropic prescription in family practice. METHODS In family practices in the Netherlands, ...
BACKGROUND We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly. DESIGN OF STUDY Case-crossover design. METHODS AND MATERIALS Elderly enrollees (n = 6010) in Taiwan's National Health Insurance Research Database with zolpidem or benzodiazepine use were analyzed for the risk of developin...
Benzodiazepine enhancement of GABA(A) receptor current requires a gamma subunit, and replacement of the gamma subunit by the delta subunit abolishes benzodiazepine enhancement. Although it has been demonstrated that benzodiazepines bind to GABA(A) receptors at the junction between alpha and gamma subunits, the structural basis for the coupling of benzodiazepine binding to allosteric enhancement...
The effects of benzodiazepine inverse agonists on the long-term potentiation of synaptic transmission in hippocampal slices of the guinea pig were examined using an extracellular recording technique. Benzodiazepine inverse agonists, beta-carboline-3-carboxylate (beta-CCE), 2-phenylpyrazolo [4,3-c]quinolin-3(5H)-one (CGS-8216) and 2-[5-methylthien-3-yl]-2,5-dihydro-3H-pyrazolo [4,3-c]quinolin-3-...
PURPOSE To evaluate the effectiveness and tolerability of pregabalin in the management of the discontinuation of benzodiazepines in long-term users. SUBJECTS AND METHODS We performed a 12-week, prospective, uncontrolled, non-interventional, and observational study in patients aged 18 years old or above, who met DSM-IV-TR criteria for benzodiazepine dependence without other major psychiatry di...
OBJECTIVES Investigate the acceptability of financial incentives for initiating a medically supervised benzodiazepine discontinuation programme among people with long-term benzodiazepine use and to identify programme features that influence willingness to participate. METHODS We conducted a discrete choice experiment in which we presented a variety of incentive-based programs to a sample of o...
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