In the title compound, C(15)H(10)F(2)O(2)S, the S=O and the 4-fluoro-phenyl groups are located on opposite sides of the plane of benzofuran ring system, and the 4-fluoro-phenyl ring is nearly perpendicular to the benzofuran plane with a dihedral angle of 89.93 (4)°. In the crystal structure, mol-ecules are linked by weak inter-molecular C-H⋯O hydrogen bonding and C-H⋯π inter-actions.

In the title compound, C(20)H(20)O(4)S, the 4-hydroxy-phenyl ring is rotated out of the plane of the benzofuran unit by 32.87 (8)°. The S-C(meth-yl) bond is almost perpendicular to the plane of the benzofuran fragment [77.8 (1)°] and is slightly tilted towards it. The crystal structure is stabilized by inter-molecular O-H⋯O and C-H⋯O hydrogen bonds.

In the title compound, C(15)H(10)F(2)O(2)S, the O atom and the methyl group of the methyl-sulfinyl substituent lie on opposite sides of the plane through the benzofuran fragment. The 4-fluoro-phenyl ring is rotated out of the benzofuran plane by a dihedral angle of 28.09 (3)°. The crystal structure is stabilized by weak inter-molecular C-H⋯O and C-H⋯F hydrogen bonds.

Benzofuranones have attracted considerable attention with regard to their pharmaceutical activity and the various approaches directed towards their synthesis .The simple benzofuran derivatives like 2-nitrobenzofuran, 2-acetyl benzofurans are well known as bio-dynamic agents possessing various pharmacological properties.spasmolytic activity on the intestine of the guinea pig and dilatory effects...

A re-examination of cuticular components of Heliotropium filifolium allowed the isolation of four new compounds: 3'-hydroxy-2',2',6'-trimethyl-3H-spiro[1-benzo-furan-2,1'-cyclohexane]-5-carboxylic acid(2), methyl 3'-acetyloxy-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylate (3), methyl 3'-isopentanoyloxy-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carbox...

A series of N-(2-(benzoyl/4-chlorobenzoyl)-benzofuran- 3-yl)-2-(substituted)-acetamide derivatives (4a-l, 5a-l) was synthesized in good yield. All synthesized compounds were in agreement with elemental and spectral data. The anticonvulsant activity of all synthesized compounds was assessed against the maximal electroshock induced seizures (MES) model in mice. Neurotoxicity was evaluated using t...

For the human health, Mycobacterium tuberculosis (MTB) is the deadliest enemy since decades due to its multidrug resistant strains. During latent stage of tuberculosis infection, MTB consumes nitrate as the alternate mechanism of respiration in the absence of oxygen, thus increasing its survival and virulence. NarL is a nitrate/nitrite response transcriptional regulatory protein of two-componen...

this study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (spbf) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. these benzofuran derivatives may be useful amyloid imaging agents for detecting b-amyloid plagues in the brain of alzheimer’s disease. the precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...

Thiazolidine-4-one substituted 1, 2, 4triazole and benzofuran heterocyclic have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A literature survey indicates that benzofuran derivatives possess different pharmacological and biological activities, of which the most potent is anti-micr...

[reaction: see text] A synthetic approach to malibatol A featuring a novel benzofuran synthesis is described.