Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, search for new therapeutics ongoing. Endolichenic fungi produce a whale of lot secondary metabolites, therapeutic effects are being evaluated. Here, we used crude extract s...

As an addictive substance, nicotine has been suggested to facilitate pro-survival activities (such as anchorage-independent growth or angiogenesis) and the establishment of drug resistance to anticancer therapy. Tobacco smoking consists of a variety of carcinogens [such as benzopyrene (BP) and nitrosamine derivatives] that are able to cause DNA double strand breaks. However, the effect of nicot...

Introduction: A small-cell lung carcinoma is an aggressive form of cancer that strongly associated with cigarette smoking and tends to early disseminate in the body. It represents about 20 per cent all cancer. Increasing evidence has implicated autocrine growth loops, proto-oncogenes, tumour-suppressor genes its development as well smoking, exposure occupational carcinogens such radon, asbestos...

We assessed the effects of in vivo phototherapy of Gunn rats on the activity of hepatic microsomal mixed-function monoxygenases and on the in vivo pharmacokinetics of [14C]HB. In experiment 1 no serial changes were seen in activities of hexobarbital hydroxylase or benzo(a)pyrene hydroxylase in hepatic microsomes isolated after 2, 4 or 7 days from homozygous jaundiced female Gunn rats exposed to...

Hepatic ethoxyresorufin 0-de-ethylase (EROD) and benzo(a)pyrene hydroxylase (B(a)PH) activity in flounder Platichthys flesus increased along a pollution gradient in Langesundfjord, examined during the GEEP Workshop. EROD activity in fish from a reference site was around 100 pm01 min-' mg microsomal protein-', increasing 5-fold at 2 moderately polluted sites and a further 2-fold at a more highly...

We describe studies carried out in the DNA context to test how a common fluorescence quencher, dabcyl, interacts with oligodeoxynucleoside fluorophores (ODFs)--a system of stacked, electronically interacting fluorophores built on a DNA scaffold. We tested twenty different tetrameric ODF sequences containing varied combinations and orderings of pyrene (Y), benzopyrene (B), perylene (E), dimethyl...

Primary Chinese hamster embryo cell cultures generally yield cell lines with a finite lifetime in culture. However, if early-passage cells are exposed chronically to either of two normal degradation products of transfer RNA, 1-methylguanine or 7-methylguanine, they are converted to con tinuous lines with altered growth characteristics and mor phology. The continuous cell lines have saturation d...