Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

The title compound {systematic name: 2-[7-fluoro-3,4-di-hydro-3-oxo-4-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetra-hydro-1H-iso-indole-1,3(2H)-dione}, C19H15FN2O4, is a dicarboximide herbicide. The dihedral angle between the male-imide and benzene ring planes is 66.13 (5)°. In the crystal, C-H⋯O and C-H⋯F hydrogen bonds and weak C-H⋯π inter-actions [3.5601 (19) Å] link adjacent mol-ec...

2-Benzoylamino-N-phenyl-benzamide derivatives (5a-h) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4a-h in the presence of a Keggin-type heteropolyacids series (H₃PW12O40·13H₂O; H₄SiW12O40·13H₂O; H₄SiMo12O40·13H₂O; and H₃PMo12O40·13H₂O) as catalysts without solvent and under microwave irradiation. We found that the use of H₃PW12O40·13H₂O acid coupled to microw...

In the title compound, C14H8N4O6, the benzoxazin-4-one fused-ring system (r.m.s. deviation = 0.018 Å) is coplanar with the attached benzene ring [dihedral angle = 0.81 (4)°], there being an intra-molecular N-H⋯N hydrogen bond between them. Each nitro group is twisted out of the plane of the attached benzene ring [O-N-C-C torsion angles = 167.94 (11) and 170.38 (11)°]. In the crystal, amine-nitr...

The hitherto unknown bis[quinazolin-4-one-2-yl]-m-phenylene (2d), and its 3-N-substituted derivatives were prepared from the corresponding bis[3,1-benzoxazin-4-one-2-yl]-m-phenylene (1) as precursor. The quinazolinone derivative 2d was converted into bis[quinazolin-4-thioxo-2-yl]-m-phenylene (3) via different routes, bis[4-chloroquinazolin-2-yl]-m-phenylene (8) and bis[4-hydrazinoquinazolin-2-y...

significant role in the rejection of the pathogen,i'2) Avenalumins consist of 3 components; the chemical structure ef the major component, avenalumin t, has been established to be 2-[2-(4hydroxyphenyl)ethenyl]-6-4H-3,1-benzoxazin-4-onc (1), based on an MS analysis of its acetylated derivative and identification of the methanolysis products.3) However, chem{cal studies by Crombie and Mistry4) ha...

In the crystal structure of title compound, C(16)H(14)ClNO(2), the dihedral angle between the aromatic rings is 4.2 (2)°.