Background: Patients with beta-thalessemia major present with severe anemia and need continous transfusion therapy. An important complication of beta-thalessemia major is iron deposition in cardiac tissue, resulting in fibrosis and dysfunction. Cardiac involvement is the major cause of death in beta-thalessemia major. The purpose of this study was to assess cardiac disease patients with bet...

4.1 Absorption, distribution, metabolism and excretion The disposition of various formulations of oral contraceptives used in humans differs. In general, both the oestrogenic and progestogenic compounds in combined oral contraceptives are absorbed by the gut and metabolized largely in the liver. A fraction of the absorbed dose of ethinyloestradiol and several progestogens is excreted in the bil...

capacity was saturated by an acute intravenous infusion of iron, deposited a large fraction of intestinally absorbed iron in the liver during the first pass of portal venous blood through this organ.1 Subsequently, Wheby and Umpiere demonstrated similar results in normal human subjects given sufficient iron to acutely saturate their plasma iron-binding capacity.2 Our results in patients with sp...

The feasibility of disrupting a tumor's vascular structure with various radiation types and radionuclides is investigated. Calculated absorbed dose profiles for photons and (4)He ions suggest that low-energy beta-gamma and alpha emitting radionuclides can deposit sufficient absorbed dose to disrupt a tumor's vascular structure while minimizing the dose outside the blood vessel. Candidate radion...

A correlation has been established between the absorbed fraction of training-set molecules after oral administration in humans and the Quantum Mechanical Polar Surface Area (QMPSA). This correlation holds for the QMPSA calculated with structures where carboxyl groups are deprotonated. The correlation of the absorbed fraction and the QMPSA calculated on the neutral gas phase optimized structures...

The sensitivity to different relevant parameters of the absorbed fraction of alpha particles emitted from the 222Rn chain in sensitive cells of the tracheo-bronchial tree have been investigated. The structure of the airway wall given by ICRP (ICRP66) has been adopted and employed in the present calculations. The source thickness (mucous gel and sol + cilia), target layer thickness and the depth...

Novel lead oxide-based flexible dosimeters with superior performance were experimentally tested for electron therapy. However, absorbed/transmitted primary particle fraction and secondary radiation distribution from the dosimeter surface have not been reported. These features should be specified to improve dosimeter’s reliability medical applications. Hence, absorbed fraction, transmitted radia...

The purpose of this study was to validate an analytical expression for the absorbed-dose calculation from the spherical source of beta-emitting radionuclides and to apply it to micrometastases treated with radiolabeled monoclonal antibodies. The self-absorbed fractions from I-131 and P-32 uniform spherical sources were calculated using the analytical expression introduced by P. K. Leichner (J. ...

The internal dosimetry schema of the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine has provided a broad framework for assessment of the absorbed dose to whole organs, tissue subregions, voxelized tissue structures, and individual cellular compartments for use in both diagnostic and therapeutic nuclear medicine. The schema was originally published in 1968, r...

1. Antibody produced in the horse migrates as a new serum component between the beta and gamma components, whereas rabbit antibody is electrophoretically identical with the gamma globulin component of the serum. 2. In rabbit and monkey antisera the percentage of antibody in the serum and in the gamma globulin fraction can be determined by integration of the electrophoresis diagrams of unabsorbe...