PURPOSE The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. METHODS EAU was induced by S-antigen peptide in Lewis rats. Accumulation of systemic...

A simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {PSL}, dexamethasone {DEX}, prednisone {PS}, betamethasone sodium phosphate {BEP} and hydrocortisone {HYD} has been developed. The method involves the oxidation of corticosteroids by iron (III) and subsequent complexation of iron (II) with potassium hexacynoferrate (III),...

Synthetic glucocorticoids are commonly given to pregnant women when premature delivery threatens. Antenatal administration of clinically relevant doses of betamethasone to pregnant sheep causes sex-specific compromises of renal function and increases in blood pressure in adult offspring. However, it is unclear whether such effects are present in immature lambs. Therefore, the aims of the presen...

Clobetasone butyrate has been formulated as a new steroid preparation of use in ophthalmology and has been compared with prednisolone phosphate and betamethasone phosphate in the treatment of anterior uveitis. The results from 4 double-blind, between-patient studies have shown that all 3 treatments are effective in reducing the signs and symptoms of this intraocular disease. 87% of those patien...

A simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {PSL}, dexamethasone {DEX}, prednisone {PS}, betamethasone sodium phosphate {BEP} and hydrocortisone {HYD} has been developed. The method involves the oxidation of corticosteroids by iron (III) and subsequent complexation of iron (II) with potassium hexacynoferrate (III),...

BACKGROUND Despite the widespread use of antenatal corticosteroids to prevent respiratory distress syndrome in preterm infants, there is currently no consensus as to the type of corticosteroid to use; nor the dose, frequency or timing of use or the route of administration. OBJECTIVES To assess the effects of different corticosteroid regimens for women at risk of preterm birth. SEARCH STRATE...

Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels these biomedical applications was evaluated. were synthesized by free-radical polymerization using a concentration components. The characterized Fourier ...

a simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {psl}, dexamethasone {dex}, prednisone {ps}, betamethasone sodium phosphate {bep} and hydrocortisone {hyd} has been developed. the method involves the oxidation of corticosteroids by iron (iii) and subsequent complexation of iron (ii) with potassium hexacynoferrate (iii),...