An effective strategy for preventing rabies consists of controlling rabies in the host reservoir with vaccination. Rabies vaccine has proven to be the most effective weapon for coping with this fatal viral zoonotic disease of warm-blooded animals, including human. Natural rabies infection of an individual is always associated with exposure to rabid animals, and the duration of clinical signs ca...

Taiwan had been free of indigenous human and animal rabies case since canine rabies was eliminated in 1961. In July 2013, rabies was confirmed among three wild ferret-badgers, prompting public health response to prevent human rabies cases. This descriptive study reports the immediate response to the reemergence of rabies in Taiwan. Response included enhanced surveillance for human rabies cases ...

OBJECTIVE To determine incidence of and risk factors for adverse events associated with distemper and rabies vaccine administration in ferrets. DESIGN Retrospective cohort study. ANIMALS 3,587 ferrets that received a rabies or distemper vaccine between January 1, 2002, and December 31, 2003. PROCEDURES Electronic medical records were searched for possible vaccine-associated adverse events...

background: during the one-year period from may 2008 to may 2009, a nationwide shortage developed which rabies vaccine was not being produced by the manufacturers. in order to manage existing supply, a protocol was established wherein an authorization was required from the regional poison center before vaccine could be administered to a patient. methods: the georgia poison center internal datab...

Rabies is a vaccine-preventable fatal zoonotic disease. Uganda, through the veterinary surveillance system at National Animal Disease Diagnostics and Epidemiology Centre (NADDEC), captures animal bites (a proxy for rabies) on monthly basis from districts. We established trends of incidence corresponding post-exposure prophylactic anti-rabies vaccination in humans (PEP), associated mortality rat...

BACKGROUND The rabies virus causes a fatal encephalitis and can be transmitted through organ transplantation. In 2013, a man developed rabies 18 months after receiving a kidney from a donor with rabies, who was not known to have been infected when the organs were procured. Three additional persons who received organs from the same donor (liver, kidney, heart), all of whom were not vaccinated fo...

background: nanoparticles have been considered as promising tools because of their high applicability. recently, nanoparticles have been evaluated for their ability to increase the immune responses as adjuvants. silver-nanoparticles (agnps) have shown promising results in enhancing th-2 immune responses and to produce potent neutralizing antibodies. neutralizing antibodies are considered as the...

Rabies is a fatal acute viral zoonosis, causing 62,000 human deaths every year. The oral rabies vaccination (ORV) programs of foxes, the main reservoir of rabies in Europe, are the most effective tools to control and finally to eradicate the disease. In order to characterize by in vivo and in vitro assays a vaccine rabies strain isolated from a rabid cattle following the ORV program, it has bee...

Rabies is an acute, fatal, neurological disease that affects almost all kinds of mammals. Vaccination (using an inactivated rabies vaccine), combined with administration of rabies immune globulin, is the only approved, effective method for post-exposure prophylaxis against rabies in humans. In the search for novel rabies control and treatment strategies, live-attenuated viruses have recently em...

Rabies encephalitis has a classical clinical presentation and its diagnosis is unmistakable. In about a fifth of cases rabies occurs as its paralytic form, which lacks the classic symptoms and may mimic other diseases, especially acute disseminated encephalomyelitis (ADEM). Magnetic resonance imaging of the brain in rabies shows a distinct abnormal pattern that differentiates it from ADEM. Henc...