To successfully apply RNAi, the very first step is to design functional siRNA or shRNA sequences targeting specific genes. Many characteristics of functional synthetic siRNAs have been identified, but it remains questionable if these characteristics can be equally applied to the design of functional shRNAs. Our three-phase algorithm was developed based on the characteristics of functional siRNA...

A family CL of circuits of a matroid M is a linear class if, given a modular pair of circuits in CL, any circuit contained in the union of the pair is also in CL. The pair (M, CL) can be seen as a matroidal generalization of a biased graph. We introduce and study an OrlikSolomon type algebra determined by (M, CL). If CL is the set of all circuits of M this algebra is the Orlik-Solomon algebra o...

‎In this paper‎, ‎we study the convex combinations of harmonic mappings obtained by shearing a class of slit conformal mappings‎. ‎Sufficient conditions for the convex combinations of harmonic mappings of this family to be univalent and convex in the horizontal direction are derived‎. ‎Several examples of univalent harmonic mappings constructed by using these methods are presented to illustrate...

The purpose of this work is to investigate the existence of fixed points of some mappings in fixed point theory by combining some important concepts which are F-weak contractions, multivalued mappings, integral transformations and α-admissible mappings. In fixed point theory, it is important to find fixed points of some classess under F- or F-weak contractions. Also multivalued mappings is the ...

We study convergence group actions on continua, and give a criterion which ensures that every global cut point is a parabolic fixed point. We apply this result to the case of boundaries of relatively hyperbolic groups, and consider implications for connectedness properties of such spaces.

We prove a strong convergence result for a sequence generated by Halpern's type iteration for approximating a common fixed point of a countable family of quasi-Lipschitzian mappings in a real Hilbert space. Consequently, we apply our results to the problem of finding a common fixed point of asymptotically nonexpansive mappings, an equilibrium problem, and a variational inequality problem for co...

In this paper, we introduce $rho$-altering $J$-type mappings in modular spaces. We prove some fixed point theorems for $rho$-altering and $rho$-altering $J$-type mappings in modular spaces. We also furnish illustrative examples to express relationship between these mappings. As a consequence, the results are applied to the existence of solution of an integral equation arising from an ODE ...

In this article, we introduce the multi-$m$-Jensen mappings and characterize them as a single equation. Using a fixed point theorem, we study the generalized Hyers-Ulam stability for such mappings. As a consequence, we show that every multi-$m$-Jensen mappings (under some conditions) is hyperstable.