The intramolecular [3+2] cycloaddition (32CA) of alkene-tethered α-silyloxydiazoalkanes provides variable stereoselectivity in generating bicyclic pyrazolines where the silyloxy group is either syn or anti to the newly formed pyrazoline ring. To elucidate the origin of the stereoselectivity, density functional theory (DFT) calculations were carried out for the energy of each transition state st...

A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and >10 : 1 dr.

Intramolecular [2+2] cycloaddition of γ,δ-unsaturated ketenes derived from hex-5-enoyl chloride derivatives gave bicyclo[2.1.1]hexan-5-ones with complete regioselectivity.

We report the synthesis and properties of alkynyl-functionalised and -bridged bicyclo[1.1.1]pentane derivatives consisting of the heavier group 14 elements silicon and tin.

Abstract Invited for this month's cover picture is the group of synthetic and physical chemists from Czech Academy Sciences. The shows electrochemical dechlorination polychlorinated derivatives bicyclo[1.1.1]pentane‐1,3‐dicarboxylic acid. Read full text Article at 10.1002/celc.202100372 .

Experimental and simulated ESR data are in good agreement with a biradical mechanism for the intramolecular pericyclic reactions of bicyclo[1.1.0]butanes.

The acetone sensitized photolysis of the title compound gave 2-(2- oxopropy1)-9,9- dimethyl bicyclo [3.3.l]nona-3-one. A bridgehead cyclopropane intermediate was then suggested for the formation of the photoproduct

Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical applicat...

Medium-sized ynolides were prepared by the Lewis acid-mediated fragmentation of bicyclic γ-silyloxy-β-hydroxy-α-diazolactones in which the Cβ-Cγ bond is the ring fusion bond. Although these lactone fragmentation substrates reacted somewhat less efficiently than their carbocyclic counterparts, the fragmentation provided 11-membered ynolides in up to 84% yield. Unlike prior fragmentations of simi...