The use of contact lenses (CLs) has been widely associated with corneal alterations that range in symptomatology and severity. Lesions may vary from small peripheral sterile infiltrates to infectious central ulcers with sight-threatening potential. Contact lens wear has been described as the most important predisposing factor to microbial keratitis worldwide. Infections are more frequent in sof...

BACTERIAL KERATITIS Simple, uninfected cases of corneal ulceration can be treated with prophylactic antibiotics, mydriatics and systemic antiinflammatory agents. However, aggressive medical therapy is indicated in all cases of confirmed or suspected bacterial keratitis. This includes topical and systemic antimicrobial drugs, mydriatics and antiproteases, and sysemic non-steroidal antiinflammato...

Microbial keratitis is a major cause of corneal opacity and loss of vision worldwide. Ulcerative microbial keratitis remains a leading cause of blindness worldwide. The most common causative organisms are bacteria, although fungi and protists can also cause keratitis. Bacterial keratitis is potentially more devastating ocular infection. The most common bacteria associated with corneal ulcer are...

PURPOSE CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier. The aim of this study is to determine (1) whether CD36 is required for the maintenance of the corneal epithelial barrier to infection, and (2) whether CD36-deficient mice present with an...

CASE REPORT A 33-year-old woman with superficial and deep bilateral corneal vascularization and keratoconjunctivitis sicca, keratoerythema and neurosensory deafness, was diagnosed with keratitis-ichthyosis-deafness (KID) syndrome. DISCUSSION KID syndrome is a congenital ectodermal dysplasia characterized by the association of vascularizing keratitis, hyperkeratotic skin lesions and sensorineu...

Pseudomonas aeruginosa and Staphylococcus aureus are the two dominant Gram-negative -positive species, respectively, isolated from patients with contact lens-related bacterial keratitis. The clinical features of keratitis vary, such that timely differential diagnosis can be challenging, which may cause a delay in resulting poorer outcome. This review aims to explore current understanding immuno...

BACKGROUND The baseline data pertaining to the national epidemiological survey of infectious keratitis remain scarce in China, and currently there is no corneal blindness control strategy developed by the nation. METHODS Geographically defined cluster sampling was used to randomly select a cross-section of residents from representative urban and rural populations in Hubei Province. Participan...