HYPOTHESIS Pheochromocytoma can be safely treated laparoscopically; "subclinical" pheochromocytoma is increasingly common. DESIGN Retrospective review. SETTING University hospital. PATIENTS Patients undergoing adrenalectomy for pheochromocytoma at our institution in 1994 to 2009. INTERVENTIONS Laparoscopic, hand-assisted, and open adrenalectomy. MAIN OUTCOME MEASURES Preoperative and ...

A 31-year old woman was admitted to our clinic complaining of high blood pressure, dizziness, constipation, mental irritability and weight loss. The physical examination revealed goiter in her neck. The plasma levels of norepinephrine and epinephrine were 3.45 and 0.76 ng/ml, respectively. Urinary excretion of norepinephrine was 1 mg and epinephrine was 32.2 micrograms/24-hours. The examination...

OBJECTIVE The aim of this case study is to emphasize the importance of α-blockade in managing a rare complication of an untreated pheochromocytoma. CLINICAL PRESENTATION AND INTERVENTION A 41-year-old man with previous bilateral pheochromocytoma presented with chest pain. He was suffering from cardiac failure and persistent hypotension requiring an inotrope. Cardiac markers, an electrocardiog...

OBJECTIVES To describe the clinical presentation and outcome of surgery in children with pheochromocytoma in a tertiary care hospital in India. METHODS Clinical records of 24 children who were operated between January 1990 and January 2011 were reviewed. The diagnosis of familial disease was established based on clinical examination and follow-up events. RESULTS Familial, bilateral, extra-a...

We describe a novel hereditary cancer syndrome in the rat that is transmitted by a recessive gene mutation. Animals exhibiting the mutant phenotype develop multiple neuroendocrine malignancies within the first year of life. The endocrine neoplasia is characterized by bilateral adrenal pheochromocytoma, multiple extra-adrenal pheochromocytoma, bilateral medullary thyroid cell neoplasia, bilatera...

Pheochromocytomas and paragangiomas are a class of neuroendocrine tumors with a widely variable clinical presentation ranging from paroxysmal episodes of critically elevated blood pressure to no clinical symptoms. Genetic predisposition to pheochromocytomas is well documented. Initial workup entails biochemical evaluation of urine catecholamine metabolites, intravenous contrast enhanced anatomi...