Bilayer tablets of Domperidone (IR) Rabeprazole (SR) were formulated for the management of gastro esophageal disorder.Immediate layer of Domperidone formulated using Tulsion T-339 as super disintegrant. For sustained release of Rabeprazole HPMC as the rate controlling polymers was used. Preformulation studies were performed prior to compression. The individual layers of the bilayer tablets were...

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion ti...

Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second ...