Alcoholic fatty liver disease (AFLD) is a major risk factor for cirrhosis-associated liver diseases. Studies demonstrate that alcohol increases serum bile acids in humans and rodents. AFLD has been linked to cholestasis, although the physiologic relevance of increased bile acids in AFLD and the underlying mechanism of increasing the bile acid pool by alcohol feeding are still unclear. In this s...

A novel location of the bile-acid-conjugating enzyme bile acid-CoA:amino acid N-acyltransferase (BAT) has been discovered in the cytosolic fraction of rat kidney. Both taurine and glycine were utilized as substrates. Formation of bile acid N-acyl amidates was verified by h.p.l.c. by comparison with authentic standards and by specific hydrolysis using cholylglycine hydrolase. Immunoblot analysis...

MECHANISMS OF PANCREATIC ADAPTATION , MOLECULAR REGULATION OF PANCREATIC ADAPTATION . Dietary changes and molecular adaptation . Peptides and molecular adaptation . BILIARY SECRETION A N D DIETARY FAT . BILE RESPONSE TO DIETARY FAT . Bile salts . Biliary phospholipids . Biliary cholesterol. . Relative proportions of biliary lipids : saturation of bile with cholesterol MECHANISMS OF BILE RESPONS...

ile acids are amphipathic molecules synthesized Bfrom cholesterol in the liver, and bile acid synthesis represents the most critical mechanism to remove cholesterol from the body. Bile acids are known to undergo enterohepatic circulation, and in the small intestines they facilitate the absorption of lipids and lipid-soluble vitamins. Bile acids have also emerged as important signaling molecules...

Although dietary factors influence bile lithogenicity and gallstone formation, the main dietary effect appears to be indirect, depending on an interaction between caloric consumption and gender-specific aspects of lipoprotein metabolism. Excessive energy intake elicits its detrimental effect by altering lipoprotein and hepatic cholesterol metabolism in association with hyperinsulinemia. Factors...

A report on the effects of primary bile acid ingestion alone or in combination with plant sterols on serum cholesterol levels, biliary lipid secretion, and bile acid metabolism. Biliary bile acid and cholesterol secretion were measured in four patients with type IIa hypercholesterolemia before and after randomized treatment periods. During these periods either a bile acid mixture (cholicchenode...