نتایج جستجو برای: binding mode
تعداد نتایج: 632612 فیلتر نتایج به سال:
Journal:
:Current Topics in Medicinal Chemistry
2019
Journal:
:Seibutsu Butsuri
2005
Journal:
:Neuron
2014
Jens Niewoehner
Bernd Bohrmann
Ludovic Collin
Eduard Urich
Hadassah Sade
Peter Maier
Petra Rueger
Jan Olaf Stracke
Wilma Lau
Alain C. Tissot
Hansruedi Loetscher
Anirvan Ghosh
Per-Ola Freskgård
Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB). We report that by manipulating the binding mode of an antibody fragment to the transferrin receptor (TfR), we have developed a Brain Shuttle module, which can be engineered into a standard therapeutic antibody for successful BBB transcyt...
Journal:
:Protein Engineering, Design and Selection
1999
Journal:
:Applied Physics Letters
2011
Journal:
:Proceedings of the National Academy of Sciences
2017
Journal:
:International Journal of Molecular Sciences
2012
Journal:
:Acta Crystallographica Section A Foundations and Advances
2019
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