BACKGROUND Mastoid obliteration seeks to replace an open mastoid cavity with material that will become viable and free of infection and cholesteatoma. The purpose of this study was to evaluate the efficacy of bioactive glass ceramic particles for mastoid obliteration using a guinea pig animal model. MATERIALS AND METHODS Ten male guinea pigs (weighing 250-300 g) with normal eardrums and Preye...

Nanoscale bioactive glasses have been gaining attention due to their superior osteoconductivity when compared to conventional (micron-sized) bioactive glass materials. The combination of bioactive glass nanoparticles or nanofibers with polymeric systems enables the production of nanocomposites with potential to be used in a series of orthopedic applications, including tissue engineering and reg...

INTRODUCTION This study aimed to evaluate the potential applications of polycaprolactone (PCL)/submicron bioactive glass (smBG) hybrid composites for pulp and dentin tissue regeneration. METHODS PCL/smBG hybrid composites were made with novel monodispersive bioactive glass submicrospheres, and pure PCL and bioactive glass samples were used as controls. Surface characteristics were assessed by...

Responses of mesenchymal stem cells (MSCs) cultured with zinc-added (2 and 5%) bioactive glass granules were evaluated in terms of cell growth and osteogenic differentiation. MSCs were cultured with different quantities (3, 10 and 30) of glass granules for up to 21 days in the osteogenic medium. Cell growth was stimulated by a small quantity of glasses, particularly those that contained zinc. O...

In this paper synthesis and characterization of a bioactive calcium phosphate glass-ceramic is presented, synthesized using a facile method. The glass-ceramic samples are synthesized with heat treating the parent glass at appropriate temperatures, where different calcium phosphate crystalline phases are grown in the parent glass samples during the heat treatment. The amounts of elements a...

BACKGROUND The greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. Nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase biomineralization for periodontal regeneration and dental implants. Considering the fact that interaction between periodontal cells and bone gr...

The purpose of this study was the histomorphologic analysis of the efficacy of bioactive glass particles with a narrow size range (Biogran) in the periodontal healing of 2-wall intrabony defects in monkeys. The 2-wall defects were made in the mesial area of the left and right second premolars of four monkeys, filled with gutta-percha and, after 15 days, they were debrided and either naturally f...

In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e. 45S5, S53P4 and 1-98) and one slowly resorbing glass, FL107, with two differe...

Biointerface design that targets osteogenesis is a growing area of research with significant implications in biomedicine. Materials known to either support or stimulate osteogenesis are composed of a biomimetic ceramic material, such as bioactive glass. Bioactive glass is osteoproductive, and the potential for osteoproductivity can be enhanced by the addition of proteins or other additives desi...