Background Traditionally, the plants were used for various diseases and disorders, including neuronal disorders. The present study was designed to evaluate neuroprotective effect of Acanthus maderaspatensis L. against colchicine induced neurobehavioral biochemical changes in Alzheimer’s disease rat model. Method Neuroprotective activity carried out by on Sprague-Dawley rats. Test group animals ...

Background. Although today primary hyperparathyroidism and cancers are considered the main factors of hypercalcemia (HC), latter is quite often detected in various endocrinopathies. According to modern data, ionized calcium (Ca2+) an intracellular mediator functioning enzymes hormones. All this determines importance finding out features associations between HC biochemical indicators endocrine d...

The major components of our diet, namely, carbohydrates, fats, proteins, vitamins, and minerals provide for the building blocks besides serving as metabolic fuel to fulfil bioenergetic needs. Since they serve basic cellular needs, are considered ‘primary metabolites’. molecular biochemical pathways modulated by food diet well-established. Many phytochemicals referred ‘secondary metabolites’ not...

A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced a...

Empirical evidence challenges the discriminant validity of the "biologically based mental illness" (BBMI) construct. Data indicate that interventions such as psychotherapy, placebo, and medication yield similar changes in brain function when effective. Drug and brain imaging studies show that psychological and biochemical phenomena can be manipulated reciprocally. Data suggest that mental disor...

The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in living systems under stress or aging. A crucial question in this context is why only certain protei...

leukodystrophies are familial disorders with onset usually in infancy or childhood. the name comes from the greek leuko meaning white and dystrophy meaning imperfect growth or development. leukodystrophy is a progressive, genetic disorder with an autosomal recessive or x-linked mode of inheritance. the clinical features consist of motor dysfunction with varying degrees of cognitive decline. mag...

This paper describes our present strategy for the investigation of respiratory chain disorders in humans. Because very few of the underlying mutations causing mitochondrial disorders in humans are currently known, biochemical studies constitute a major tool in screening procedures for respiratory chain deficiencies. All biochemical and molecular methods described are scaled-down methods, allowi...