نتایج جستجو برای: biochemical profiling
تعداد نتایج: 215812 فیلتر نتایج به سال:
conclusions in conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low. background diabetes is an alarmingly increasing public health concern. according to a world health organization (who) report, diabetes is highly prevalent in almost all regions...
Molecular profiling of primary tumors may facilitate the classification of patients with cancer into more homogenous biological groups to aid clinical management. Metabolomic profiling has been shown to be a powerful tool in characterizing the biological mechanisms underlying a disease but has not been evaluated for its ability to classify cancers by their tissue of origin. Thus, we assessed me...
Protein S-prenylation is a lipid modification that regulates membrane-protein and protein-protein interactions in cell signaling. Though sites of protein S-prenylation can be predicted based upon conserved C-terminal CaaX or CC/CXC motifs, biochemical detection of protein S-prenylation in cells is still challenging. Herein, we report an alkynyl-isoprenol chemical reporter (alk-FOH) as an effici...
Proteases are one of the largest and best-characterized families of enzymes in the human proteome. Unfortunately, the understanding of protease function in the context of complex proteolytic cascades remains in its infancy. One major reason for this gap in understanding is the lack of technologies that allow direct assessment of protease activity. We report here an optimized solid-phase synthes...
Depth profiling of Oxygen in the surface of materials is important for many oxide elements. In this research two methods of ion beam analysis techniques were used for depth profiling of oxygen in nanoporous anodic Alumina by Nuclear Reaction Analysis (NRA) ( 16O(d, p1)17O ,16O(d, p0)17O) and resonant elastic scattering (RES)( 16O(α, α)16O). By using simulation software, variation of oxygen conc...
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