TP53 acts as a tumor suppressor in cancer. It induces cell cycle arrest or apoptosis in response to cellular stress and damage. p53 gene alteration could cause uncontrolled cell proliferation.In the present study, we used TP53 gene as the seed in the construction of a protein-protein functional association network to identify genes that might involve in tumorgenesis process with TP53. TP53 prot...

A novel algorithm for the fast detection of hubs in chemical networks is presented. The algorithm identifies a set of nodes in the network as most significant, aimed to be the most effective points of distribution for fast, widespread coverage throughout the system. We show that our hubs have in general greater closeness centrality and betweenness centrality than vertices with maximal degree, w...