Abstract DNA methylation is one of the best-known epigenetic modifications in mammals. The alteration of DNA methylation patterns has been found to be related to many diseases, including cancer. It is well-known that during carcinogenesis, a site-specific DNA hypermethylation and a global DNA hypomethylation take place. This overall loss of DNA methylation has been proposed as a valid biomarker...

The last ten years has seen an explosion in interest in epigenetic mechanisms of control of gene expression. This is particularly true in the field of cancer research where epigenetic alterations are now regarded as equally important as genetic alterations in the development and progression of cancer. Of particular interest is altered DNA methylation, which is a key feature of essentially all t...

the present study was focused upon the assessment of acetyl-cholinesterase (ache) activity in the digestive gland (main metabolic center) and foot (highly innervated organ) of the green garden snail, cantareus apertus (born, 1778), exposed to different nominal dietary concentrations of pb (25 and 2500 mg pb/kg), cd (10 and 100 mg cd/kg) and their combination (25 mg pb + 10 mg cd/kg and 2500 mg ...

salman and resalat oilfields are such marine oilfields that are in vicinity of each other. there is resalat oilfield in distance about 80-90 kilometers from lavan island in persian gulf. this oilfield is located in 25 kilometer southwest in reshat oilfield. salman oilfield is located in vicinity of water border line of united arab emirate in 140 kilometers of south of lavan island. this oilfiel...

soils bacteria are frequently faced with various adverse environmental conditions and have developed a complex regulatory network to respond rapidly to environmental changes. in this study usefulness and applicability of stress proteins of bacteria which are produced after stress conditions were examined. the adaptation of soil bacteria involves the induction of stress proteins provide a nonspe...

cancer has been always in a great attention in the field of molecular biology. by applying    large-scale tools such as advanced proteomics, cancer diagnosis and treatment have been improved greatly since. cancers of esophagus, gastric, and colon accounted for major health problem globally. biomarker panel could bring out the accuracy for cancer evaluation tests as it can suggest a group of can...

Clinical studies on MET-targeting cancer therapeutics have yielded mixed results in recent years, and MET-relevant predictive biomarkers remain elusive. New studies now reveal METex14 alternative splicing aberrations to represent potential predictive cancer genomic biomarker, hence renewing optimism and directions in the quest for optimized MET-targeting personalized cancer therapy.

Genetic variation within homogeneous gene pools in various crops is assumed to be very limited. One objective of this study was to use 144 simple sequence repeat (SSR) markers to determine if the single-plant lines selected at ultra-low plant density in honeycomb designs within the soybean cultivars Benning, Haskell, and Cook had unique SSR genetic fingerprints. Another objective was to investi...

Analysis of the brain specific biomarkers amyloid beta(42) (Abeta(42)) and total tau (t-tau) protein in cerebrospinal fluid (CSF) has a sensitivity and specificity of more than 85% for differentiating Alzheimer's Disease (AD) from non-demented controls. International guidelines are contradictory in their advice on the use of CSF biomarkers in AD diagnostics, resulting in a lack of consistency i...

the aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction (iugr) during 16 th week of gestation. plasma was obtained from primiparous women during 16 th week of gestation. 2-de proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women wh...