Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which ...

The reaction in ether-methanol between 2'-deoxyguanosine and diazomethane or its ethyl or n-butyl homologue gives 1-, O(6)- and 7-alkyl-2'-deoxyguanosine. N(2),O(6)-Dimethyl-2'-deoxyguanosine was also detected. The hydrolysis of the methyl and the ethyl derivatives gives the corresponding alkylguanines: the O(6)-alkyl-2'-deoxyguanosines were sequentially hydrolysed, first to 2-amino-6-alkoxypur...

A study has been conducted to determine whether lithium magnesiates are feasible candidates for the enantioselective deprotonation of 4-alkylcyclohexanones. The commercially available chiral amine (+)-bis[(R)-1-phenylethyl]amine (2-H) was utilised to induce enantioselection. When transformed to its lithium salt and combined with (n)Bu2Mg, improved enantioselective deprotonation of 4-tert-butylc...

This work presents the results of studying behavior catalytic systems formed on basis trichlorotris-(tetrahydrofuranate)chromium(III) in presence sulfur-containing tridentate SOS-type ligands and activated by various organoaluminum compounds. In formation systems, following compounds were used: - bis-(2-methylthioethyl) ether, bis-(2-ethylthioethyl) ether bis-(2-phenylthioethyl) triethylaluminu...

Bis(2-chloro-1-methylethyl) ether is a beta-haloether and a byproduct of propylene oxide and propylene glycol manufacture. A bioassay of technical grade bis(2-chloro-1-methylethyl) ether for possible carcinogenicity was conducted by administering the test chemical by gavage to F344 rats. Groups of 50 rats of each sex were administered a solution of bis(2-chloro-1-methylethyl) ether in corn oil ...

New examples of ansa-titanocenes derived from 1,2-bis(2-indenyl)ethane have been prepared. The titanium-mediated reductive coupling of 2-(hydroxymethyl)indenes provided a convenient method for substrate dimerization. Alkyl substitution of the indene ring at C(3) improved the regioselectivity of the reductive coupling to provide the ethylene bis(2-indenyl)ansa-ligands in 29–62% yield.

A variety of natural products and synthetic molecules cause mitotic arrest by interfering with microtubule function, and a few molecules of this mechanistic class are anticancer drugs. The ustiloxin and phomopsin families of natural products (Scheme 1) are potent microtubule depolymerizers isolated from the fungus species Ustilaginoidea virens and Phomopsis leptostromiformis, respectively. Memb...

A liquid-crystalline benzocrown ether, 4'-[(4''-1,1,2,2-tetrahydroperfluorooctyloxy)biphenyloxycarbonyl]benzo-15-crown-5, was used as a neutral carrier of ion-selective electrodes (ISEs) to elucidate the effect of highly ordered assembling of the neutral carrier on the sensor properties through fluorophilic interactions. The properties for the membrane and the resulting ISEs based on a benzocro...