Women have higher post PCI bleeding complications which in turn contributes to higher post PCI mortality. Bivalirudin decreases bleeding events in both men and women when compared to use of both heparin and GPI but bleeding avoidance strategies such as radial artery access or avoiding GPI may modify that benefit. The NCDR bleeding risk score incorporates gender and is predictive of both bleedin...

This paper considers how results from clinical trials should be applied in the care of patients, using the results of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial of tranexamic acid in bleeding trauma patients as a case study. We explain why an understanding of the mechanisms of action of the trial treatment, and insight into the factors that migh...

How observers distribute limited processing resources to regions of a scene is based on a dynamic balance between current goals and reflexive tendencies. Past research showed that these reflexive tendencies include orienting toward objects that expand as if they were looming toward the observer, presumably because this signal indicates an impending collision. Here we report that during visual s...

The modern movable-Do solmization system based on syllables devised by Guido d'Arezzo was modified and pieced together over centuries by various scholars and pedagogues, each with their own rationale. To date, considerations of the movable-Do system have not sufficiently examined the effects of the vowels contained within its solfège syllables. While vowels have been thoroughly analyzed among v...

Corresponding author: Dr. Thach Nguyen, MD, St. Mary Medical Center, 1500 South Lake Park Ave, Hobart IN 46342, USA. E-mail: [email protected] In general, percutaneous coronary intervention (PCI) is contra-indicated in patients with bleeding and those that are easy to bleed because during PCI the patients need full anticoagulation to counter any thrombotic formation caused by introduction and ma...

Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time. Aspirin exerts these effects by irreversibly blocking cyclooxygenase and, therefore, its actio...

UNLABELLED During the first 6 weeks after a variceal hemorrhage there is a 30-40% of probability of recurrence and those who rebleed 20- 30% die. Passed this period, the risk of rebleeding is of 60% and reaches a mortality of 60-70% in two years without treatment. OBJECTIVE Describe the frequency of rebleeding and mortality due to rebleeding in cirrhotic patients treated for variceal hemorrha...

In a prospective double-blind trial, we treated 194 patients with acute venous thromboembolism with heparin or low molecular weight heparin (LMWH; Fragmin). To evaluate the most important prognostic factors for bleeding, the presenting clinical features of the patients, the patients' anticoagulant responses, and the doses of the drugs were analyzed using univariate and multivariate regression a...