Background: Hyperthyroidism as a risk factor for stroke is not conclusive. There are no definite data on the relationship between ischemic cerebrovascular injury and hyperthyroidism. This study was designed to define whether the outcomes of post-ischemic stroke injury are influenced by chronic hyperthyroidism. Methods: Two groups of hyperthyroid (HT) and control euthyroid rats of equal numbers ...

A targeted drug delivery system is based on a technique that continuously administers predetermined dosage of therapeutic agent to sick location the body. The goal raise relative amount treatment in target tissues while lowering it non-target tissues. This technique's intrinsic benefit has been reduced dose and adverse effects. Drug targeting brain one most challenging issues pharmaceutical res...

Introduction: Microbubbles are widely used as contrast agent in diagnostic ultrasound. Recently they have shown good potential for applications in the therapeutic field such as drug delivery to the brain. Recent studies have shown focused ultrasound in conjunction with injected micro-bubbles could temporarily disrupt blood-brain barrier and let therapeutic agents transport into...

Development of an in vitro cell culture system to mimic the blood-brain barrier p. 117 The development of ion regulation at the blood-brain barrier p. 123 An approach to study of transport of trace metals at the blood-brain barrier p. 133 Bidirectional passage of peptides across the blood-brain barrier p. 139 Localization patterns for immunoglobulins and albumins in the brain suggest diverse me...

Objective: Measurement of blood-brain permeability dysfunction in active and chronic MS lesions with T1-weighted dynamic contrast-enhanced MRI to show variation in inflammatory activity Background: blood-brain-barrier perfusion characterization impaired in MS as some studies have shown recently buta comparison between perfusion parameters in contrast-enhanced and non-enhanced lesions not have ...