IL-2 exerts multiple biological activities upon binding to its specific cell surface receptors. The IL-2 receptor (IL-2R) is composed of at least two subunits, the p55 (CD25/Tac) and the p75 glycoproteins. p55 and p75 both bind IL-2 independently with either low or intermediate affinity, respectively, whereas a heterodimeric receptor composed of p55 and p75 binds IL-2 with high affinity (1, 2) ...

Remarkable advances in our understanding of innate and adaptive immunity have shed light on why inflammation is centrally involved in the pathogenesis of many diseases traditionally not viewed as primarily inflammatory in nature. One key area of progress has been the discovery and study of innate immune receptors, referred to as pattern recognition receptors (PRRs), such as toll-like receptors ...

AimNeurofilament light chain (NfL) is recognized as a blood biomarker in several neurodegenerative disorders, but its possible relevance Ataxia Telangiectasia (A-T) has not been examined. The aim of this study was to investigate the potential NfL concentrations patients with A-T.MethodBlood (serum/plasma) were measured Dutch and an American cohort A-T compared control values. Additionally, corr...

seroepidemiological investigation of hepatitis b,c and hiv virus in safe blood donors of babol blood transfusion center   aghajanipoor k.1,2 (md), zandieh t.1(phd)      1 iranian blood transfusion organization-research center   2 amol regional blood transfusion center