OBJECTIVES We examined the lytic effects of anti-glycoprotein (GP) IIb/IIIa agents on platelet thrombi formed on the collagen surface under blood flow conditions. BACKGROUND Anti-GP IIb/IIIa agents may influence platelet thrombi already formed. METHODS Blood samples were anticoagulated either by the specific antithrombin Argatroban (100 microM) or by unfractionated heparin (0.1 U/ml). After...

This paper demonstrates a non-Fourier prediction methodology of triple-layer human skin tissue for determining burn injury with non-ideal properties tissue, metabolism and blood perfusion. The dual-phase lag (DPL) bioheat model is employed solved using joint integral transform (JIT) through Laplace Fourier transforms methods. Parametric studies on the effects properties, initial temperature, pe...

The liver is among the organs that trap lymphocytes flowing through their blood vasculature. These cells, marginated in sinusoids, participate in the liver's anti-viral and anti-tumor processes. The molecular mechanism of this lymphocyte margination and cooperation with resident sinusoidal cells remains obscure and inadequately studied due to the difficulties in obtaining samples of sinusoidal ...

OBJECTIVE To investigate the effect of position and size of tumor region of interest (ROI) on the estimation of lung cancer vascular parameters using 256-slice computed tomography (CT) perfusion. METHODS After institutional review board approval and written informed consent, 16 men and 11 women with lung cancer were enrolled in this CT perfusion study. Perfusion, blood volume, and peak enhanc...

Limited information is available about selection of the threshold for arterial blood pressure in critically ill patients, particularly in sepsis when normal organ blood flow autoregulation may be altered. The present experimental study investigated whether increasing perfusion pressure using norepinephrine in normotensive hyperdynamic porcine bacteremia affects intestinal macro- and microcircul...

Many common diseases involve impaired tissue perfusion, and heterogeneous distribution of blood flow in the microvasculature contributes to this pathology. The physiological mechanisms regulating homogeneity/heterogeneity of microvascular perfusion are presently unknown. Using established empirical formulations for blood viscosity modeling in vivo (blood vessels) and in vitro (glass tubes), we ...

OBJECTIVE During selective cerebral perfusion (SCP), only the upper body is perfused. However, blood actually returns into the descending aorta through collaterals during SCP. This collateral blood flow (CBF) is thought to be important to protect the visceral organs and spinal cord from ischemia. The left subclavian artery is postulated to be important as a collateral source to the lower body. ...

BACKGROUND: When measuring skin blood perfusion with laser-Doppler methods in a limb, a non-zero perfusion is sometimes registered even when the arterial inflow to, and venous outflow from the site of measurement is arrested using proximal cuff compression pressures well in excess of systolic blood pressure. This residual signal, known as the biological zero (BZ)1-7, is present to some extent w...

Background: Psoriasis is one of the most commonly recognized dermatological diseases, characterized by distinct structural changes, hyperproliferation and inflammation. The aim study was quantitative comparisons psoriatic skin with without lesions non-invasive imaging methods. Methods: 71 patients diagnosed psoriasis vulgaris underwent at site lesion such lesion. Skin density, epidermis thickne...