•Eptifibatide mediates potent antithrombotic effects when used in primary PCI. •Standard eptifibatide infusion for several hours increases bleeding complications. •A novel, short regimen retains ischemic protection during •Bleeding complications are greatly reduced by the abbreviated regimen. •Avoiding prolonged treatment may improve clinical outcomes. The glycoprotein IIb/IIIa inhibitor eptifi...

There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...

Abstract This study evaluated the impact of different gluten-free bread's inner structure on oral processing and texture perception. Four rice-based breads were prepared varying water hydration (H: 85 or 100 g water/100 g flour) fermentation time (F: 30 75 min). Mechanical properties breads, bolus (after three chews at swallowing point), subject's chewing activities, perceived sensations using ...

OBJECTIVES The efficacy of high dose furosemide as a continuous infusion was compared with a bolus injection of equal dose in patients with severe heart failure. BACKGROUND The delivery rate of furosemide into the nephron has been proved to be a determinant of diuretic efficacy in healthy volunteers. METHODS In a randomized crossover study we compared the efficacy of a continuous infusion o...

Date Approved: [Month dd, yyyy] iii ACKNOWLEDGEMENTS I would like to thank my family, especially my parents, for their continued support for me throughout every phase of my life. In addition I would like to thank my research advisor Dr. Omer T. Inan for allowing me to have the opportunity to research in his lab; I will be forever grateful for the knowledge and experience I have gained during th...

Intraluminal impedance, a nonradiological method for assessing bolus flow within the gut, may be suitable for investigating pharyngeal disorders. This study evaluated an impedance technique for the detection of pharyngeal bolus flow during swallowing. Patterns of pharyngoesophageal pressure and impedance were simultaneously recorded with videofluoroscopy in 10 healthy volunteers during swallowi...

BACKGROUND Many patients do not intensify their insulin regimens. It is believed that lack of adherence may be largely due to fear of hypoglycemia. We hypothesized that utilization of an automated bolus calculator (bolus advisor) might reduce fear of hypoglycemia and encourage patients to achieve improved glycemic control. METHOD We surveyed 1,412 type 1 diabetes mellitus (T1DM) patients trea...

We examined the measurement error in inhaled and exhaled aerosol concentration resulting from the bolus delivery system when small volumes of monodisperse aerosols are inspired to different lung depths. A laser photometer that illuminated approximately 75% of the breathing path cross section recorded low inhaled bolus half-widths (42 ml) and negative deposition values for shallow bolus inhalati...

AIM To assess the diagnostic accuracy and radiation dose of split-bolus multidetector-row computed tomography (MDCT) protocol in the detection and characterization of focal liver lesions in oncologic patients. PATIENTS AND METHODS We retrospectively analyzed triphasic CT at initial diagnosis and follow-up split-bolus 64-detector row CT protocol in 48 oncologic patients with focal liver lesion...

PURPOSE To investigate the incremental diagnostic value of dual-bolus over single-contrast-bolus first pass magnetic resonance myocardial perfusion imaging (MR-MPI) for detection of significant coronary artery disease (CAD). MATERIALS AND METHODS Patients (n = 49) with suspected CAD underwent first pass adenosine stress and rest MR-MPI and invasive coronary angiography (CA). Gadolinium diethy...