Osteoporosis can manifest in two ways in rheumatoid arthritis: generalized bone loss, which may result from immobility, the inflammatory process per se and/or treatments such as steroids; and periarticular demineralization, which is probably due to local release of inflammatory agents. Digital X-ray radiogrammetry (DXR) is an effective and sensitive modality for monitoring periarticular osteopo...

We performed multiple analyses of Tyrannosaurus rex (specimen MOR 1125) fibrous cortical and medullary tissues remaining after demineralization. The results indicate that collagen I, the main organic component of bone, has been preserved in low concentrations in these tissues. The findings were independently confirmed by mass spectrometry. We propose a possible chemical pathway that may contrib...

Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization a...

Osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K. Current imaging modalities are insufficient for sensitive observation of osteoclast activity, and in vivo live imaging of osteoclast resorption of bone has yet to be demonstrated. Here, we describe a near-infrared fluorescence reporter probe who...

The decrease in tissue hypoxia obtained with Hyperbaric Oxygenation (HBO2)counteracts the effects of reflex vasomotor disturbances caused by an injury in posttraumatic Sudeck's syndrome. In reflex sympathetic dystrophy, after an initial vasospasm, a loss of vascular tone with persistent vasodilatation. Causes increased osseous vascularity and rapid bone resorption. Chronic edema results from ve...

Allogenic demineralized bone matrix has been developed as a reliable alternative to the autologous graft. In present study, we assessed osteoformation potential of partially (PDBM) in paste form obtained without an added carrier. This formulation included preparation cancelous from femoral heads after decellularision, delipidation, demineralization HCl and autoclaving at 121 °C. Structural bioc...

Sex hormones like estrogen and progesterone are responsible for physiological changes in women at specific phases of their life. Menopause is associated with symptoms of estrogen deficiency. Estradial levels fall gradually in the years before menopause. Levels of folliclestimulating hormone (FSH) and luteinizing hormone (LH) begin to rise and the levels of sex hormones begin to fluctuate. This ...