If dental implantology is an increasingly successful treatment modality, why should we still need to understand the mechanisms of peri-implant bone healing? Are there differences in cortical and trabecular healing? What does "poor quality" bone mean? What stages of healing are most important? How do calcium phosphate-coated implants accelerate healing? What is the mechanism of bone bonding? Whi...

Background and Aim: Despite the advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams. Effects of sildenafil and pentoxifylline on healing of bone fractures have not been well investigated. This study aimed to assess the effects of sildenafil and pentoxifylline phosphodiesterase inhibitors on healing of mandibular fractures in rats. Materials and Methods...

Objective- To evaluate the role of greater omentum incorporation of coral in healing of the long bone defect in dog model. Design- Experimental in-vivo study. Animals- Sixteen adult mongrel male dogs weighing 26.2±2.5 kg, free of evident infectious or parasitic illnesses were used in this study. Procedures- The operative procedure was undertaken under general anesthesia. Radial bone was expo...

This study aimed at investigating if a coating of hydroxyapatite nanocrystals would enhance bone healing over time in trabecular bone. Sandblasted and acid etched titanium implants with and without a submicron thick coat of hydroxyapatite nanocrystals (nano-HA) were implanted in rabbit femur with healing times of 2, 4, and 9 weeks. Removal torque analyses and histological evaluations were perfo...

Our contemporary understanding of bone healing has evolved due to knowledge gleaned from a continuous interaction between basic laboratory investigations and clinical observations following procedures to augment healing of fractures, osseous defects, and unstable joints. The stages of bone healing parallel the early stages of bone development. The bone healing process is greatly influenced by a...

Objective- To evaluate tail vertebra as an autogenous cortical bone and cancellous bone for filling ulnarsegmental bone defect in dogs.Design- Experimental study.Animals- Eight adult mongrel dogs with an aver age age of 37.S months and average body wei ght of17.62 kg.Procedure- Th e animals were randomly divided into two groups . A bone defect (2.S-cm) was created onthe middle po rtion of the r...

OBJECTIVES Direct current, capacitive coupling, and inductive coupling are modes of electrical stimulation (ES) used to enhance bone healing. It is important to assess the effectiveness of ES for bone healing to ensure optimization for clinical practice. This review aims to examine the level of evidence (LOE) for the application of ES to enhance bone healing and investigate the proposed mechani...

Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fract...

Bone fracture is a very common body injury. The healing process is physiologically complex, involving both biological and mechanical aspects. Following a fracture, cell migration, cell/tissue differentiation, tissue synthesis, and cytokine and growth factor release occur, regulated by the mechanical environment. Over the past decade, bone healing simulation and modeling has been employed to und...

Metaphysis cancellous bone fracture is one of the most common fracture types in clinical orthopedic practice. The specialized healing process of cancellous bone fracture has long been ignored by the academic society. Comparing with diaphyseal cortical bone healing, cancellous bone healing showed less bone tissue necrosis, barely any hematoma formation, limited inflammation events and no externa...