PURPOSE The aim of this study was to investigate the application of the three-dimensional bone bioreactor for studying drug-release kinetics and distribution of drugs in the ex vivo cancellous bone environment, and to demonstrate the application of nanoengineered titanium (Ti) wires generated with titania nanotube (TNT) arrays as drug-releasing implants for local drug delivery METHODS Nanoeng...

Abstract Due to the material itself and traditional geometric design, short implants have problems of high stiffness, less osseointegrated area, lower long-term reliability in clinical application. In this research, with various porous structures were constructed their biomechanical responses evaluated, including properties, compression capability, stress distribution surrounding bone tissue. T...

The effect of local application of autologous platelet-rich plasma (PRP) on bone healing in combination with the use of titanium implants with 2 different surface configurations was investigated. PRP fractions were obtained from venous blood sample of 6 goats and applied via gel preparation and subsequent installation in the implant site or via dipping of the implant in PRP liquid before insert...

Objective(s): CaO–MgO–SiO2 system bioceramics possess good characteristics for hard tissue engineering applications. The aim of the study was to synthesize the nano powder by using a sol-gel method and evaluate of bioactivity in the cells culture. Methods: To characterize of powder X-ray diffraction (XRD), transmission electron microscopy (TEM) and to eva...

background and aims. the aim of this study was to evaluate the predictability of implantation at the time of maxillary and mandibular molar extraction. materials and methods. maxillary and mandibular molars were extracted with an atraumatic technique (root separation and careful extraction with a periotome) to preserve all remaining inter-radicular bone. then, 115 tapered and straight implants ...

AIM A tissue-engineered periodontal ligament (PDL) around implants would represent an important new therapeutic tool to replace lost teeth. The PDL is the key to tooth anchoring; it connects tooth root and alveolar bone, and it sustains bone formation. MATERIALS AND METHODS Cells were isolated from PDL and cultured in a bioreactor on titanium pins. After the formation of multiple cellular lay...

INTRODUCTION Mini-implants are often immediately loaded for orthodontic treatment; however, changes in interfacial tissues caused by early loading and its effects might compromise the mini-implant's function. The purpose of this study was to compare the healing of interfacial tissues 1, 4, and 12 weeks after the placement of titanium-alloy mini-implants in New Zealand rabbits; some of the impla...

BACKGROUND Simvastatin increases the expression of bone morphogenetic protein 2 (BMP-2) in osteoblasts, therefore it is important to investigate the influence of statins on bone formation, fracture healing and implant integration. The aim of the present study was to investigate the effect of simvastatin, locally applied from intramedullary coated and bioactive implants, on bone integration usin...

results the mean distances between the crestal bone and the implant shoulder in group 1 were 1.01, 1.44, and 1.93 mm at the implant placement time, and at the 6 and 12-month postoperative intervals, respectively. in group 2, these distances were 1.35, 1.20, and 1.41 mm, respectively. there were no significant differences in the marginal bone resorption between the two groups (p > 0.05). conclus...