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A 49-year-old man was admitted due to fever, arthralgia, and diarrhea of unknown origin. He had received highly active antiretroviral therapy treatment since 2006, with HIV-RNA being undetectable. Hemogram revealed macrocytic anemia (hemoglobin, 10.5 g/dL; mean corpuscular volume, 101 fL), leukopenia (2.4 G/L; lymphocytes, 2.2 G/L; neutrophils, 0.14 G/L; monocytes, 0.04 G/L; eosinophils, 0.01 G...

background: hematological abnormalities are a common complication of hiv infection and occur in all stages of the infection. these abnormalities increase as the disease advances. we aimed to evaluate the diagnostic utility of bone marrow sampling in hiv-positive patients. methods: 40 hiv-infected individuals were screened for hematological abnormalities. investigations such as iron studies, hem...

To date, 240 cases of bone marrow necrosis have been reported, of which only 13 were reported in association with chronic myelogenous leukemia (CML). Imatinib mesylate is an agent which can specifically inhibit the activity of tyrosine kinase chimeric protein BCR-ABL which is caused by the balanced translocation between the short arm of chromosome 9, and the long arm of chromosome 22, and is cl...

A patient with chronic myeloid leukaemia was treated with interferon without using conventional cytotoxic agents. Bone marrow necrosis developed at the onset of blast transformation. It is suggested that cytotoxic drugs should be given before treatment with interferon for chronic myeloid leukaemia. Cytotoxic drugs may also be needed to prevent rapid bone marrow growth once interferon has been w...