Previous studies have shown that the mechanical properties of trabecular bone are determined by bone volume fraction (BV/TV) and microarchitecture. The purpose of this study was to explore other possible determinants of the mechanical properties of vertebral trabecular bone, namely collagen cross-link content, microdamage, and mineralization. Trabecular bone cores were collected from human L2 v...

Architecture and mineralization are important determinants of trabecular bone quality. To date, no quantitative information is available on changes in trabecular bone architecture and mineralization of newly formed bone during development. Three-dimensional architecture and mineralization of the trabecular bone in the mandibular condyle from six pigs of different developmental ages were investi...

A pilot study was carried out in order to verify the pattern of changes in mineralization of bone in the maxillas and mandibles of dogs which had a tooth extraction or luxation. Bone mineral content was determined using computerized microdensitometry. Significant changes in patterns of mineralization were found for alveolar bone, cortical bone and trabecular bone at the sites adjacent to the ar...

Previously we showed that free-range hens fed diets supplemented with diatomaceous earth (DE) were significantly heavier, laid more eggs, and consumed more feed than hens fed the control diet, with no differences in feed efficiency. In the present study, we compared plasma calcium concentrations, and bone mineralization of the hens from our previous study to test the effect of DE on these param...

Egg-laying strains of chickens are highly susceptible to osteoporosis, a noninfectious disease characterized by a decrease in structural bone as hens age. To minimize the onset of osteoporosis, it was hypothesized that a delay in sexual maturity may allow a pullet to develop a stronger skeletal frame before egg laying, leading to improved skeletal mineralization at end of lay. One management to...

Calcium-containing spherical bodies (calcospherulites) exist along the mineralization front of bone and are thought to play a role in bone formation. Existing methods to isolate calcospherulites involve harsh treatments that remove much of their organic matter. This study sought to isolate them using a less destructive approach to better preserve their organic components. Juvenile rats were inj...

Annexins II, V and VI are highly expressed by hypertrophic and terminally differentiated growth plate chondrocytes and by osteoblasts. Because of the localization of annexins in areas of cartilage and bone mineralization, we hypothesized that these annexins play a regulatory role in the mineralization process. In this article we review the function of annexins II, V and VI in physiological mine...

The current bone autograft procedure for cleft palate repair presents several disadvantages such as limited availability, additional invasive surgery, and donor site morbidity. The present preliminary study evaluates the mineralization potential of electrospun polydioxanone:nano-hydroxyapatite : fibrinogen (PDO : nHA : Fg) blended scaffolds in different simulated body fluids (SBF). Scaffolds we...

Quantitative morphologic methods were used to measure the effects of feeding a low phosphorus diet to intact and thyroparathyroidectomized rats on several processes of bone mineralization and turnover. In severely hypophosphatemic animals, the matrix formation rate was decreased, the osteoid maturation rate was decreased, which indicated a delay in the onset of mineralization, the initial rate ...