background: for tissue engineering of bone, anatomical and operational reconstructions of damaged tissue seem to be vital. this is done via reconstruction of bone and appropriate biological joint with bone tissues of damaged areas. in this study the condition of biodegradable bed nano fiber phbv and ussc cells were used to accelerate bone repair of damaged area. methods: hollow nanofabrication ...

Silk fibroin (SF), chitosan (CS) and nano-hydroxyapatite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair material in bone tissue engineering. The aim of the present study was to invest...

In this study, a new concept of a 3D-printed scaffold was introduced for the accurate placement of an implant and the application of a recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded bone graft. This preliminary study was conducted using two adult beagles to evaluate the 3D-printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP)/bone decellularized extracellular matrix (bd...

Bionic modeling technology of bone defect repair plays a key role in the process of repairing defective bone based on tissue engineering. In this paper, via studying the structure of bone defect repair, new concept of bionic scaffold is put forward and a new method of integrating medical image processing, 3D reconstruction and CAD technology to construct the bionic scaffold of repairing bone de...

INVESTIGATION OF PHYSIOCHEMICAL PROPERTIES OF A NOVEL GRADIENTCALCIUM POLYPHOSPHATE BONE SCAFFOLD AND ITS INFLUENCE ONCELLULAR BEHAVIORByLIANG CHENDecember 2013Advisor: Dr. Weiping RenMajor: Biomedical EngineeringDegree: Master of ScienceA good designed bone scaffold is crucial to bone tissue engineering. We have developedand characterized a novel gradien...

The osteoconductive capacity of TiO(2) scaffolds was investigated by analysing the bone ingrowth into the scaffold structure following their placement into surgically modified extraction sockets in Gottingen minipigs. Non-critical size defects were used in order to ensure sufficient bone regeneration for the evaluation of bone ingrowth to the porous scaffold structure, and sham sites were used ...

The feasibility of bone transport with bone substitute and the factors which are essential for a successful bone transport are unknown. We studied six groups of 12 Japanese white rabbits. Groups A to D received cylindrical autologous bone segments and groups E and F hydroxyapatite prostheses. The periosteum was preserved in group A so that its segments had a blood supply, cells, proteins and sc...

A highly osteogenic hybrid bioabsorbable scaffold was developed for bone reconstruction/augmentation. Through the use of a solid free-form fabrication technology, a bioabsorbable polycaprolactone (PCL) cage scaffold with a desired size and shape was produced and then filled with osteogenic bone graft particles, that is, morselized autologous bone chips. A rabbit total lamina defect model was ch...

The study aimed to develop a chitosan (CS)-based scaffold for repairing calvarial bone defects. We fabricated composite scaffolds made of CS and bovine-derived xenograft (BDX), characterized their physicochemical properties including pore size and porosity, absorption, degradation, and compressive strength, compared their efficacy to support in vitro proliferation and differentiation of human j...

Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element...